ArticleThe Journal of clinical investigation1996
Ligand recognition by murine anti-DNA autoantibodies. II. Genetic analysis and pathogenicity.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 48 citations in OpenAlex.
- Effects of low-dose-gamma rays on the immune system of different animal models of disease.Dose-response : a publication of International Hormesis Society · 2014Article
- Impact of DNA hairpin folding energetics on antibody-ssDNA association.Journal of molecular biology · 2007Article
- Bispecific abs against modified protein and DNA with oxidized lipids.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Specific recognition of a dsDNA sequence motif by an immunoglobulin VH homodimer.Protein science : a publication of the Protein Society · 2004Article
- Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice.The Journal of experimental medicine · 2004Article
- Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.The Journal of clinical investigation · 1998Article
- Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determination.The Journal of experimental medicine · 1997Article
- An in vitro assay for detection of glomerular binding IgG autoantibodies in patients with systemic lupus erythematosus.The Journal of clinical investigation · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Although anti-DNA autoantibodies are an important hallmark of lupus, the relationships among anti-DNA structure, reactivity, and pathogenicity have not been fully elucidated. To further investigate these relationships, we compare the variable genes and primary structure of eight anti-DNA mAbs previously obtained from an MRL/MpJ-lpr/lpr mouse along with the ability of three representative mAbs to induce nephritis in nonautoimmune mice using established adoptive transfer protocols. One monospecific anti-single-stranded (ss) DNA (11F8) induces severe diffuse proliferative glomerulonephritis in nonautoimmune mice whereas another anti-ssDNA with apparently similar in vitro binding properties (9F11) and an anti-double-stranded DNA (4B2) are essentially benign. These results establish a murine model of anti-DNA-induced glomerular injury resembling the severe nephritis seen in lupus patients and provide direct evidence that anti-ssDNA can be more pathogenic than anti-double-stranded DNA. In vitro binding experiments using both protein-DNA complexes and naive kidney tissue indicate that glomerular localization of 11F8 may occur by recognition of a planted antigen in vivo. Binding to this antigen is DNase sensitive which suggests that DNA or a DNA-containing molecule is being recognized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.