ArticleThe Journal of clinical investigation1996
Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 250 citations in OpenAlex.
- Serum paraoxonase 1 activity is decreased in thyroid dysfunction.Journal of endocrinological investigation · 2003Trial
- Effect of Dietary PUFAs and Antioxidants on Antioxidant and Anti-Inflammatory Functions of HDL in a Cohort of Women.Antioxidants (Basel, Switzerland) · 2025Article
- Changes in biomarkers of redox status in serum and saliva of dogs with hypothyroidism.BMC veterinary research · 2023Article
- Article
- Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease.Archives of endocrinology and metabolism · 2021Article
- Suppression of inflammatory arthritis in human serum paraoxonase 1 transgenic mice.Scientific reports · 2020Article
- Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and activity in mice fed a high-fat diet.European journal of nutrition · 2018Article
- A Possible Mechanism: Vildagliptin Prevents Aortic Dysfunction through Paraoxonase and Angiopoietin-Like 3.BioMed research international · 2018Article
- CYP/PON genetic variations as determinant of organophosphate pesticides toxicity.Journal of genetics · 2017Review
- The role of cholesterol-enriched diet and paraoxonase 1 inhibition in atherosclerosis progression.Journal of cardiovascular and thoracic research · 2017Article
- Bis(4,4'-dimethyl-2,2'-bipyridine)oxidovanadium(IV) Sulfate Dehydrate: Potential Candidate for Controlling Lipid Metabolism?BioMed research international · 2017Article
- Increased presence of oxidized low-density lipoprotein in the left ventricular blood of subjects with cardiovascular disease.Physiological reports · 2016Article
- Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction.The Journal of biological chemistry · 2016Article
- Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex.The Journal of clinical investigation · 2013Article
- Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases.North American journal of medical sciences · 2012Article
- The effect of age on the paraoxonase and arylesterase activity of pregnant mothers and their infants.Journal of clinical laboratory analysis · 2012Article
- The human paraoxonase gene cluster as a target in the treatment of atherosclerosis.Antioxidants & redox signaling · 2012Review
- Effect of atorvastatin therapy on oxidant-antioxidant status and atherosclerotic plaque formation.Vascular health and risk management · 2011Article
- Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR-/- mice.Alcoholism, clinical and experimental research · 2010Article
- Human paraoxonase 2.EXCLI journal · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In an effort to identify genetic factors contributing to atherogenesis, we have studied inbred strains of mice that are susceptible (C57BL/6J) and resistant (C3H/HeJ) to diet-induced aortic fatty streak lesions. When maintained on a low-fat diet, HDL isolated from both strain C57BL/6J (B6) and C3H/HeJ (C3H) mice protect against LDL oxidation in a coculture model of the artery wall. However, when maintained on an atherogenic diet high in fat and cholesterol, the HDL isolated from B6 mice lose the capacity to protect, whereas HDL from C3H mice protect equally well. Associated with the loss in the ability of HDL to protect is a decrease in the activity of serum paraoxonase, a serum esterase carried on HDL that has previously been shown to protect against LDL oxidation in vitro. The levels of paraoxonase mRNA decreased in B6 mice upon challenge with the atherogenic diet but increased in C3H, indicating that paraoxonase production is under genetic control. In a set of recombinant inbred strains derived from the B6 and C3H parental strains, low paraoxonase mRNA levels segregated with aortic lesion development, supporting a role for paraoxonase in atherogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.