ArticleThe Journal of cell biology1996
Microtubule transport and assembly during axon growth.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Mini-review: Microtubule sliding in neurons.Neuroscience letters · 2021Review
- Moonlighting Motors: Kinesin, Dynein, and Cell Polarity.Trends in cell biology · 2017Review
- Stability properties of neuronal microtubules.Cytoskeleton (Hoboken, N.J.) · 2016Review
- Sliding of centrosome-unattached microtubules defines key features of neuronal phenotype.The Journal of cell biology · 2016Article
- Signaling Over Distances.Molecular & cellular proteomics : MCP · 2016Review
- Hooks and comets: The story of microtubule polarity orientation in the neuron.Developmental neurobiology · 2011Review
- The enhancement effect of beta-boswellic acid on hippocampal neurites outgrowth and branching (an in vitro study).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2010Article
- Loss of neurofilaments alters axonal growth dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching.Molecular biology of the cell · 2001Article
- Neurofilaments are transported rapidly but intermittently in axons: implications for slow axonal transport.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Glutamate slows axonal transport of neurofilaments in transfected neurons.The Journal of cell biology · 2000Article
- Reorganization and movement of microtubules in axonal growth cones and developing interstitial branches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Different contributions of microtubule dynamics and transport to the growth of axons and collateral sprouts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Slow axonal transport of neurofilament protein in cultured neurons.The Journal of cell biology · 1999Article
- STOP proteins are responsible for the high degree of microtubule stabilization observed in neuronal cells.The Journal of cell biology · 1998Article
- Microtubule transport from the cell body into the axons of growing neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Delivery of newly synthesized tubulin to rapidly growing distal axons of sympathetic neurons in compartmented cultures.The Journal of cell biology · 1996Article
- Functional analysis of dynactin and cytoplasmic dynein in slow axonal transport.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Microtubule assembly in growing dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- A composite model for establishing the microtubule arrays of the neuron.Molecular neurobiology · 1996Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is controversy concerning the mechanisms by which the axonal microtubule (MT) array is elaborated, with some models focusing on MT assembly and other models focusing on MT transport. We have proposed a composite model in which MT assembly and transport are both important (Joshi, H.C., and P.W. Baas. 1993. J. Cell Biol. 121:1191-1196). In the present study, we have taken a novel approach to evaluate the merits of this proposal. Biotinylated tubulin was microinjected into cultured neurons that had already grown short axons. The axons were then permitted to grow longer, after which the cells were prepared for immunoelectron microscopic analyses. We reasoned that any polymer that assembled or turned over subunits after the introduction of the probe should label for biotin, while any polymer that was already assembled but did not turnover should not label. Therefore, the presence in the newly grown region of the axon of any unlabeled MT polymer is indicative of MT transport. In sampled regions, the majority of the polymer was labeled, indicating that MT assembly events are active during axon growth. Varying amounts of unlabeled polymer were also present in the newly grown regions, indicating that MT transport also occurs. Together these findings demonstrate that MT assembly and transport both contribute to the elaboration of the axonal MT array.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.