ArticleJournal of cancer research and clinical oncology1996
Apoptosis of colon cancer: comparison with Ki-67 proliferative activity and expression of p53.
Article in Journal of cancer research and clinical oncology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model.Oxidative medicine and cellular longevity · 2020Article
- Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy.Acta pharmacologica Sinica · 2017Article
- Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Genetic polymorphisms and haplotypes of TRAIL gene correlate with NSCLC susceptibility in a group of Chinese patients.International journal of clinical and experimental medicine · 2015Article
- Combined analysis of biomarkers of proliferation and apoptosis in colon cancer: an immunohistochemistry-based study using tissue microarray.International journal of colorectal disease · 2014Article
- Ex vivo culture of primary human colonic tissue for studying transcriptional responses to 1α,25(OH)2 and 25(OH) vitamin D.Physiological genomics · 2014Article
- Biomarkers in precision therapy in colorectal cancer.Gastroenterology report · 2013Article
- The prognostic value of the apoptosis pathway in colorectal cancer: a review of the literature on biomarkers identified by immunohistochemistry.Biomarkers in cancer · 2013Review
- Sporadic colorectal cancer development shows rejuvenescence regarding epithelial proliferation and apoptosis.PloS one · 2013Article
- Role of CD34, vascular endothelial growth factor, and p53 in neoangiogenesis as correlated with stage of disease in colorectal carcinoma.Medical journal, Armed Forces India · 2011Article
- Chemopreventive effect of different ratios of fish oil and corn oil in experimental colon carcinogenesis.Lipids · 2010Article
- Potential role of bcl-2 and ki-67 expression and apoptosis in colorectal carcinoma: a clinicopathologic study.Digestive diseases and sciences · 2003Article
- Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer.British journal of cancer · 2001Article
- Apoptosis, proliferative activity and Bcl-2 expression in Epstein-Barr-virus-positive non-Hodgkin's lymphomas.Journal of cancer research and clinical oncology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of apoptosis in colon cancer was investigated in terms of control of growth and expression on p53, using the nick-ended-DNA labelling method and immunohistochemistry. The apoptotic labeling index was highest in the T1 stage (24 cases), as was the proliferative activity, assessed in terms of the Ki-67 labeling index. Both labeling indices demonstrated similar overall incidence curves for the total 95 colon cancer cases, and examination of individual cases revealed a statistically significant correlation (P=0.01). However, neither index had any relation to p53. The results thus suggest that apoptosis in colon cancers has a linkage with proliferative activity that can be assessed by Ki-67 labeling, but is not regulated by the p53 system. This might contribute to the diversity of colon cancer growth.
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