ArticleGenetics1995
Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Recommendations for the investigation of animal models of Prader-Willi syndrome.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Guideline
- Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of theCells · 2022Article
- Gene datasets associated with mouse cleft palate.Data in brief · 2018Article
- Creating a "hopeful monster": mouse forward genetic screens.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression.Human genetics · 2008Article
- A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color.American journal of human genetics · 2008Article
- X-ray-induced deletion complexes in embryonic stem cells on mouse chromosome 15.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Lack of Pwcr1/MBII-85 snoRNA is critical for neonatal lethality in Prader-Willi syndrome mouse models.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice.Age (Dordrecht, Netherlands) · 2005Article
- Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- Pink-eyed dilution protein modulates arsenic sensitivity and intracellular glutathione metabolism.Molecular biology of the cell · 2002Article
- Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: a fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Genetic studies at the Atomic Bomb Casualty Commission-Radiation Effects Research Foundation: 1946-1997.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Differential response of mouse male germ-cell stages to radiation-induced specific-locus and dominant mutations.Genetics · 1998Article
- A microsatellite map of the pink-eyed dilution (p) deletion complex in mouse chromosome 7.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homozygous and heterozygous phenotypes are described and characterized for 45 new pink-eyed dilution (p) locus mutations, most of them radiation-induced, that affect survival at various stages of mouse development. Cytogenetically detectable aberrations were found in three of the new p mutations (large deletion, inversion, translocation), with band 7C involved in each case. The complementation map developed from the study of 810 types of compound heterozygotes identifies five functional units: jls and jlm (two distinct juvenile-fitness functions, the latter associated with neuromuscular defects), pl-1 and pl-2 (associated with early-postimplantation and preimplantation death, respectively), and nl [neonatal lethality associated with cleft palate (the frequency of rare "escapers" from this defect varied with the genotype)]. Orientation of these units relative to genetic markers is as follows: centromere, Gas-2, pl-1, jls, jlm p, nl (equatable to cp 1 = Gabrb3); pl-2 probably resides in the c-deletion complex. pl-1 does not mask preimplantation lethals between Gas2 and p; and no genes affecting survival are located between p and cp1. The alleles specifying mottling or darker pigment (generically, pm and px, respectively) probably do not represent deletions of p-coding sequences but could be small rearrangements involving proximal regulatory elements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.