ArticleGenetics1995
An alpha tubulin mutation suppresses nuclear migration mutations in Aspergillus nidulans.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Small Sized Yet Powerful: Nuclear Distribution C Proteins in Plants.Plants (Basel, Switzerland) · 2023Review
- Kinesin-1 autoinhibition facilitates the initiation of dynein cargo transport.The Journal of cell biology · 2023Article
- The splicing-factor Prp40 affects dynein-dynactin function inMolecular biology of the cell · 2020Article
- Nuclear movement in fungi.Seminars in cell & developmental biology · 2018Review
- NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.Cell research · 2016Article
- Discovery of a vezatin-like protein for dynein-mediated early endosome transport.Molecular biology of the cell · 2015Article
- The Aspergillus nidulans bimC4 mutation provides an excellent tool for identification of kinesin-14 inhibitors.Fungal genetics and biology : FG & B · 2015Article
- Cytoplasmic dynein and early endosome transport.Cellular and molecular life sciences : CMLS · 2015Review
- FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus.Molecular biology of the cell · 2014Article
- HookA is a novel dynein-early endosome linker critical for cargo movement in vivo.The Journal of cell biology · 2014Article
- Identification of a novel site in the tail of dynein heavy chain important for dynein function in vivo.The Journal of biological chemistry · 2013Article
- LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules.Scientifica · 2013Review
- Structural features and chaperone activity of the NudC protein family.Journal of molecular biology · 2011Article
- The mammalian NudC-like genes: a family with functions other than regulating nuclear distribution.Cellular and molecular life sciences : CMLS · 2009Review
- Timely septation requires SNAD-dependent spindle pole body localization of the septation initiation network components in the filamentous fungus Aspergillus nidulans.Molecular biology of the cell · 2009Article
- The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies.Eukaryotic cell · 2008Article
- Neuronal migration: unraveling the molecular pathway with humans, mice, and a fungus.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Review
- Article
- Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.Cell · 2007Article
- CLIP-170 homologue and NUDE play overlapping roles in NUDF localization in Aspergillus nidulans.Molecular biology of the cell · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Microtubules and cytoplasmic dynein, a microtubule-dependent motor, are required for nuclei to move along the hyphae of filamentous fungi. Nuclear migration in Aspergillus nidulans is blocked by heat-sensitive (hs-) mutations in the nudA gene, which encodes dynein heavy chain, and the nudF gene, which encodes a G protein beta-subunit-like protein. Hs- mutations in the nudC and nudG genes also prevent nuclear migration. We have isolated extragenic suppressor mutations that reverse the hs- phenotypes caused by these mutations. Here we show that one nudF suppressor also suppresses hs- mutations in nudA, nudC, and nudG and deletions in nudA and nudF. This suppressor mutation is in the tubA alpha tubulin gene, and its characteristics suggest that it destabilizes microtubules. The mutation alters microtubule staining and confers sensitivity to cold and benomyl, two treatments that destabilize microtubules. Treatment with low concentrations of benomyl also suppresses the hs- nudA, nudC, nudF, and nudG mutations and the nudA and nudF deletions. Suppression of the hs- nudA mutation and the nudA deletion is especially interesting because these strains lack active dynein heavy chain. Together, these results suggest that microtubule destabilization allows nuclei to migrate even in the absence of cytoplasmic dynein motor function.
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Registered trials
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