ArticleChromosoma1996
HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes.
Article in Chromosoma, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 102 citations in OpenAlex.
- Use of hyaluronan in the selection of sperm for intracytoplasmic sperm injection (ICSI): significant improvement in clinical outcomes--multicenter, double-blinded and randomized controlled trial.Human reproduction (Oxford, England) · 2013Trial
- The synaptonemal complex: structure, function, and clinical implications†.Biology of reproduction · 2026Article
- UBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice.iScience · 2025Article
- High fat diet-induced obesity and gestational DMBA exposure alter folliculogenesis and the proteome of the maternal ovary†.Biology of reproduction · 2024Article
- Review
- What's Genetic Variation Got to Do with It? Starvation-Induced Self-Fertilization Enhances Survival in Paramecium.Genome biology and evolution · 2020Article
- Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics.Trends in genetics : TIG · 2018Review
- Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice.Biology of reproduction · 2018Article
- Heat Shock Protein 40 (HSP40) in Pacific White Shrimp (Frontiers in physiology · 2018Article
- Regulating the construction and demolition of the synaptonemal complex.Nature structural & molecular biology · 2016Review
- Disrupting Cyclin Dependent Kinase 1 in Spermatocytes Causes Late Meiotic Arrest and Infertility in Mice.Biology of reproduction · 2015Article
- Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humans.Cell stress & chaperones · 2015Review
- HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis.Molecular biology of the cell · 2014Article
- Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study.Histochemistry and cell biology · 2011Article
- The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse.PloS one · 2010Article
- Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse.Biology of reproduction · 2009Article
- The expression pattern of the 70-kDa heat shock protein Hspa2 in mouse tissues.Histochemistry and cell biology · 2009Article
- Regulation of the meiotic prophase I to metaphase I transition in mouse spermatocytes.Chromosoma · 2008Article
- Sperm chromatin: fertile grounds for proteomic discovery of clinical tools.Molecular & cellular proteomics : MCP · 2008Review
- Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis.The Journal of cell biology · 2008Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Mouse spermatogenic cells are known to express HSP70-2, a member of the HSP70 family of heat-shock proteins. The purpose of the present study was to characterize further the expression and localization of HSP70-2 in meiotic cells of mice and hamsters. After separating mouse spermatogenic cells into cytoplasmic and nuclear fractions, proteins were separated by two-dimensional gel electrophoresis and detected with HSP-specific antibodies. Of several HSP70 proteins identified in the cytoplasm, only HSC70 and HSP70-2 were also detected in the nucleus. Immunocytological analyses of spermatocyte prophase cells revealed that HSP70-2 was associated with the synaptonemal complex. Surface-spread synaptonemal complexes at pachytene and diplotene stages labeled distinctly with the antiserum to HSP70-2. Synaptonemal complexes from fetal mouse oocytes failed to show any evidence of HSP70-2. Reverse-transcriptase-polymerase chain reaction (RT-PCR) analyses of gene expression confirmed this sex specificity; Hsp70-2 mRNA was detected in mouse testes, but not ovaries. These findings are suggestive of a previously unsuspected sexual dimorphism in structure and/or function of the synaptonemal complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.