ArticleBMJ (Clinical research ed.)1996
Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years.
Article in BMJ (Clinical research ed.), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 4 of them syntheses that pooled it.
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Who cites it
134 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Neonatal outcomes after in utero exposure to antipsychotics: a systematic review and meta-analysis.European journal of epidemiology · 2024Pooled it
- Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta-Analysis of 7 646 267 Participants From 135 Studies.Journal of the American Heart Association · 2018Pooled it
- Metabolic signatures of birthweight in 18 288 adolescents and adults.International journal of epidemiology · 2016Pooled it
- Mode of delivery and offspring body mass index, overweight and obesity in adult life: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Blood pressure and the capacity-load model in 8-year-old children from Nepal: Testing the contributions of kidney size and intergenerational effects.American journal of human biology : the official journal of the Human Biology Council · 2016Trial
- Birth weight and cognitive performance in older women: the Rancho Bernardo study.Archives of women's mental health · 2010Trial
- Randomized controlled trial of feeding a concentrated formula to infants born to women infected by human immunodeficiency virus.Journal of pediatric gastroenterology and nutrition · 2009Trial
- AA and Pregnancy.Reviews of physiology, biochemistry and pharmacology · 2027Review
- Gestational Diabetes Risk May Vary Depending on Birth Month.Journal of clinical medicine · 2025Article
- Reduced type 2 diabetes incidence reflecting end of post-World War II calorie restrictions in Germany.Diabetologia · 2024Article
- Reduced type 2 diabetes incidence reflecting end of post‑World War II calorie restrictions in Germany. Reply to Nilsson PM, Vaag A [letter].Diabetologia · 2024Article
- Preeclampsia and the Antiphospholipid Syndrome.Biomedicines · 2023Review
- [Short stature due to intrauterine growth retardation. Clinical and hormonal-metabolic features, possibilities of growth-stimulating therapy].Problemy endokrinologii · 2022Article
- Early life programming of health and disease: The long-term consequences of obesity in pregnancy.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Review
- Physique at Birth and Cardiovascular Disease Risk Factors in Japanese Urban Residents: the KOBE Study.Journal of atherosclerosis and thrombosis · 2022Article
- Low Birth Weight, β-Cell Function and Insulin Resistance in Adults: The Brazilian Longitudinal Study of Adult Health.Frontiers in endocrinology · 2022Article
- Personalization of medical treatments in oncology: time for rethinking the disease concept to improve individual outcomes.The EPMA journal · 2021Review
- Revisiting Regulators of Human β-cell Mass to Achieve β-cell-centric Approach Toward Type 2 Diabetes.Journal of the Endocrine Society · 2021Review
- Maternal Proinflammatory Adipokines Throughout Pregnancy and Neonatal Size and Body Composition: A Prospective Study.Current developments in nutrition · 2021Article
- Exposure to obesogenic endocrine disrupting chemicals and obesity among youth of Latino or Hispanic origin in the United States and Latin America: A lifecourse perspective.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Review
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo establish whether the relation between size at birth and non-insulin dependent diabetes is mediated through impaired beta cell function or insulin resistance.
designCohort study.
settingUppsala, Sweden. SUBJECTS: 1333 men whose birth records were traced from a cohort of 2322 men born during 1920-4 and resident in Uppsala in 1970.
main outcome measuresIntravenous glucose tolerance test at age 50 years and non-insulin dependent diabetes at age 60 years.
resultsThere was a weak inverse correlation (r=-0.07, P=0.03) between ponderal index at birth and 60 minute insulin concentrations in the intravenous glucose tolerance test at age 50 years. This association was stronger (r=-0.19, P=0.001) in the highest third of the distribution of body mass index than in the other two thirds (P=0.01 for the interaction between ponderal index and the body mass index). Prevalence of diabetes at age 60 years was 8% in men whose birth weight was less than 3250 g compared with 5% in men with birth weight 3250 g or more (P=0.08; 95% confidence interval for difference -0.3% to 6.8%). There was a stronger association between diabetes and ponderal index: prevalence of diabetes was 12% in the lowest fifth of ponderal index compared with 4% in the other four fifths (P=0.001; 3.0% to 12.6%).
conclusionThese results confirm that reduced fetal growth is associated with increased risk of diabetes and suggest a specific association with thinness at birth. This relation seems to be mediated through insulin resistance rather than through impaired beta cell function and to depend on an interaction with obesity in adult life.
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