ArticleBiophysical journal1995
Membrane mechanics can account for fusion pore dilation in stages.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 76 citations in OpenAlex.
- Bimodal Mechanical Response of Membrane Necks: Implications for the Nuclear Envelope.ACS nano · 2026Article
- The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores.eLife · 2021Article
- Curvature Energetics Determined by Alchemical Simulation on Four Topologically Distinct Lipid Phases.The journal of physical chemistry. B · 2021Article
- Article
- Article
- Asymmetric Phosphatidylethanolamine Distribution Controls Fusion Pore Lifetime and Probability.Biophysical journal · 2017Article
- Palmitoylation Contributes to Membrane Curvature in Influenza A Virus Assembly and Hemagglutinin-Mediated Membrane Fusion.Journal of virology · 2017Article
- Mechanics of post-fusion exocytotic vesicle.Physical biology · 2017Article
- Article
- Article
- Fusion pores and their control of neurotransmitter and hormone release.The Journal of general physiology · 2017Review
- Article
- Cholesterol Increases the Openness of SNARE-Mediated Flickering Fusion Pores.Biophysical journal · 2016Article
- Calculating Transition Energy Barriers and Characterizing Activation States for Steps of Fusion.Biophysical journal · 2016Article
- A continuum model of docking of synaptic vesicle to plasma membrane.Journal of the Royal Society, Interface · 2015Article
- It's what's inside that matters.Biophysical journal · 2014Article
- Teardrop shapes minimize bending energy of fusion pores connecting planar bilayers.Physical review. E, Statistical, nonlinear, and soft matter physics · 2013Article
- Increased catecholamine secretion from single adrenal chromaffin cells in DOCA-salt hypertension is associated with potassium channel dysfunction.ACS chemical neuroscience · 2013Article
- A comparison of coarse-grained and continuum models for membrane bending in lipid bilayer fusion pores.Biophysical journal · 2013Article
- Adhesion energy can regulate vesicle fusion and stabilize partially fused states.Journal of the Royal Society, Interface · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Once formed, fusion pores rapidly enlarge to semi-stable conductance values. The membranes lining the fusion pore are continuous bilayer structures, so variations of conductance in time reflect bending and stretching of membranes. We therefore modeled the evolution of fusion pores using the theory of the mechanics of deforming homogeneous membranes. We calculated the changes in length and width of theoretical fusion pores according to standard dynamical equations of motion. Theoretical fusion pores quickly achieve semi-stable dimensions, which correspond to energy minima located in a canyon between energy barriers. The height of the barrier preventing pore expansion diminishes along the dimensions of length and width. The bottom of the canyon slopes gently downward along increasing length. As a consequence, theoretical fusion pores slowly lengthen and widen as the dimensions migrate along the bottom of the canyon, until the barrier vanishes and the pore rapidly enlarges. The dynamics of growth is sensitive to tension, spontaneous curvature, bending elasticity, and mobilities. This sensitivity can account for the quantitative differences in pore evolution observed in two experimental systems: HA-expressing cells fusing to planar bilayer membranes and beige mouse mast cell degranulation. We conclude that the mechanics of membranes could cause the phenomenon of stagewise growth of fusion pores.
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