ArticleBiophysical journal1995
Automated method for modeling seven-helix transmembrane receptors from experimental data.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 96 citations in OpenAlex.
- Molecular dynamics simulation approach for the prediction of transmembrane helix-helix heterodimers assembly.European biophysics journal : EBJ · 2007Article
- Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Structure modeling of all identified G protein-coupled receptors in the human genome.PLoS computational biology · 2006Article
- Optimal bundling of transmembrane helices using sparse distance constraints.Protein science : a publication of the Protein Society · 2004Article
- First principles predictions of the structure and function of g-protein-coupled receptors: validation for bovine rhodopsin.Biophysical journal · 2004Article
- Molecular modelling studies on the ORL1-receptor and ORL1-agonists.Journal of computer-aided molecular design · 2003Article
- Molecular modeling of interactions of the non-peptide antagonist YM087 with the human vasopressin V1a, V2 receptors and with oxytocin receptors.Journal of computer-aided molecular design · 2001Article
- Calculation of rigid-body conformational changes using restraint-driven Cartesian transformations.Biophysical journal · 2001Article
- A sequence and structural study of transmembrane helices.Journal of computer-aided molecular design · 2001Article
- Modeling and docking the endothelin G-protein-coupled receptor.Biophysical journal · 2000Article
- Visualisation and integration of G protein-coupled receptor related information help the modelling: description and applications of the Viseur program.Journal of computer-aided molecular design · 1999Article
- Structural organization of G-protein-coupled receptors.Journal of computer-aided molecular design · 1999Review
- The variable and conserved interfaces of modeled olfactory receptor proteins.Protein science : a publication of the Protein Society · 1999Article
- Structural features of heterotrimeric G-protein-coupled receptors and their modulatory proteins.Molecular neurobiology · 1999Review
- Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints.Biophysical journal · 1998Article
- Molecular modeling of the human vasopressin V2 receptor/agonist complex.Journal of computer-aided molecular design · 1998Article
- BUNDLE: a program for building the transmembrane domains of G-protein-coupled receptors.Journal of computer-aided molecular design · 1998Article
- Using experimental information to produce a model of the transmembrane domain of the ion channel phospholamban.Biophysical journal · 1998Article
- Molecular dynamics simulations of individual alpha-helices of bacteriorhodopsin in dimyristoylphosphatidylcholine. II. Interaction energy analysis.Biophysical journal · 1998Article
- Molecular dynamics of individual alpha-helices of bacteriorhodopsin in dimyristol phosphatidylocholine. I. Structure and dynamics.Biophysical journal · 1997Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
A rule-based automated method is presented for modeling the structures of the seven transmembrane helices of G-protein-coupled receptors. The structures are generated by using a simulated annealing Monte Carlo procedure that positions and orients rigid helices to satisfy structural restraints. The restraints are derived from analysis of experimental information from biophysical studies on native and mutant proteins, from analysis of the sequences of related proteins, and from theoretical considerations of protein structure. Calculations are presented for two systems. The method was validated through calculations using appropriate experimental information for bacteriorhodopsin, which produced a model structure with a root mean square (rms) deviation of 1.87 A from the structure determined by electron microscopy. Calculations are also presented using experimental and theoretical information available for bovine rhodopsin to assign the helices to a projection density map and to produce a model of bovine rhodopsin that can be used as a template for modeling other G-protein-coupled receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.