ArticleThe EMBO journal1996
Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 172 citations in OpenAlex.
- Article
- Soluble CD40 ligand inhibits the growth of non-Hodgkin's lymphoma cells through the JNK signaling pathway.Oncology letters · 2021Article
- Characteristics and clinical trial results of agonistic anti-CD40 antibodies in the treatment of malignancies.Oncology letters · 2020Review
- MKK7, the essential regulator of JNK signaling involved in cancer cell survival: a newly emerging anticancer therapeutic target.Therapeutic advances in medical oncology · 2019Review
- Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK.Experimental & molecular medicine · 2011Article
- Article
- Differential role of reactive oxygen species in the activation of mitogen-activated protein kinases and Akt by key receptors on B-lymphocytes: CD40, the B cell antigen receptor, and CXCR4.Journal of cell communication and signaling · 2007Article
- Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression.Molecular and cellular biology · 2004Article
- Microarray analysis of Aeromonas hydrophila cytotoxic enterotoxin-treated murine primary macrophages.Infection and immunity · 2004Article
- Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Prospects for CD40-directed experimental therapy of human cancer.Cancer gene therapy · 2003Review
- Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia.Journal of clinical immunology · 2002Article
- CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion.Molecular pathology : MP · 2002Article
- CD40 is expressed and functional on neuronal cells.The EMBO journal · 2002Article
- Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.The Journal of experimental medicine · 2001Article
- Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cells.Journal of virology · 2001Article
- c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.The Journal of experimental medicine · 2001Article
- Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation.The Biochemical journal · 2000Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The B cell-associated surface molecule CD40 plays a key role in T cell-dependent B cell maturation, as individuals with defects in either CD40 or its ligand are impaired in immunoglobulin isotype class switching and germinal center formation. CD40 signaling activates downstream effectors, including the tyrosine protein kinase, Lyn, the phosphatidylinositol-3-kinase (PI-3 kinase), and the transcription factor, NF-kappa B. In this study, we demonstrate that stress-activated protein kinases (SAPK) are activated after CD40 cross-linking on various B cell lines or human tonsillar B cells. The activation is rapid and transient and is mediated through a cyclosporin A-insensitive pathway. Furthermore, this signaling pathway appears not to rely on protein kinase C. While CD40 ligation strongly activates the SAPKs (up to 25-fold), it does not affect members of the mitogen-activated protein kinase family (MAPK; ERK1 and ERK2). Consistent with these data, CD40 signals up-regulate c-jun but not c-fos mRNA and alter the transcription factor ATF2 but not the Raf-1 protein. In summary, CD40 signaling preferentially induces SAPK but not MAPK.
Indexed as
Identifiers
8598210PMC449921W37150070What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.