ArticleThe EMBO journal1996
PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 141 citations in OpenAlex.
- Review
- New insights in prolactin: pathological implications.Nature reviews. Endocrinology · 2015Review
- Article
- Mutations in the exon 10 of prolactin receptor gene change the egg production performance in Wanjiang white goose.Molecular biology reports · 2012Article
- The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis.ISRN molecular biology · 2012Review
- Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells.Cellular signalling · 2011Article
- Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Protein tyrosine phosphatases in the JAK/STAT pathway.Frontiers in bioscience : a journal and virtual library · 2008Review
- Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.The Journal of biological chemistry · 2006Article
- The role of prolactin in mammary carcinoma.Endocrine reviews · 2003Review
- Src family kinases are required for prolactin induction of cell proliferation.Molecular biology of the cell · 2001Article
- SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.Genes & development · 2001Article
- Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase.Molecular and cellular biology · 1998Article
- Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction.Molecular and cellular biology · 1998Article
- Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival.The Journal of experimental medicine · 1997Article
- Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Prolactin as a mitogen in mammary cells.Journal of mammary gland biology and neoplasia · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimulation of the prolactin receptor (PRLR), a member of the cytokine/growth hormone receptor family, results in activation of the associated Jak2 tyrosine kinase and downstream signaling pathways. We report that PTP1D, a cytoplasmic protein tyrosine phosphatase containing two Src homology 2 (SH2) domains, physically associates with the PRLR-Jak2 complex and is tyrosine-phosphorylated upon stimulation with prolactin. The formation of the trimeric PRLR-Jak2-PTP1D complex is critical for transmission of a lactogenic signal, while PTP1D phosphorylation is necessary, but not sufficient. The dominant negative inhibitory effect of a phosphatase-deficient mutant on expression of a beta-casein promoter-controlled reporter gene is evidence for an essential role of fully functional PTP1D in the regulation of milk protein gene transcription.
Indexed as
Identifiers
8598196PMC449925W1931725779What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.