ArticleMammalian genome : official journal of the International Mammalian Genome Society1995
Mapping of the calcium-sensing receptor gene (CASR) to human chromosome 3q13.3-21 by fluorescence in situ hybridization, and localization to rat chromosome 11 and mouse chromosome 16.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 125 citations in OpenAlex.
- The calcium-sensing receptor in inflammation: Recent updates.Frontiers in physiology · 2022Review
- A cell function study on calcium regulation of a novel calcium-sensing receptor mutation (p.Tyr825Phe).Annals of pediatric endocrinology & metabolism · 2021Article
- International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function.Pharmacological reviews · 2020Review
- Intractable Generalized Epilepsy and Autosomal Dominant Hypocalcemia: A Case Report.Child neurology open · 2019Article
- A Novel Mutation of the Calcium-Sensing Receptor Gene Causing Familial Hypocalciuric Hypercalcemia Complicates Medical Followup after Roux-en-Y Gastric Bypass: A Case Report and a Summary of Mutations Found in the Same Hospital Laboratory.Case reports in endocrinology · 2019Article
- De novo a novel variant of CaSR gene in a neonate with congenital hypoparathyroidism.Annals of pediatric endocrinology & metabolism · 2018Article
- A Mendelian randomization study of the effect of calcium on coronary artery disease, myocardial infarction and their risk factors.Scientific reports · 2017Article
- Calcium-Sensing Receptor Gene: Regulation of Expression.Frontiers in physiology · 2016Review
- Regulation of ca(2+) signaling in pulmonary hypertension.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- A novel CASR mutation in a Tunisian FHH/NSHPT family associated with a mental retardation.Molecular biology reports · 2012Article
- Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol.World journal of gastroenterology · 2008Article
- Markedly reduced activity of mutant calcium-sensing receptor with an inserted Alu element from a kindred with familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.The Journal of clinical investigation · 1997Article
- Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators.Journal of cellular and molecular medicineReview
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8 authors at 4 institutions in 3 countries.
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Abstract
The calcium-sensing receptor (CASR), a member of the G-protein coupled receptor family, is expressed in both parathyroid and kidney, and aids these organs in sensing extracellular calcium levels. Inactivating mutations in the CASR gene have been described in familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Activating mutations in the CASR gene have been described in autosomal dominant hypoparathyroidism and familial hypocalcemia. The human CASR gene was mapped to Chromosome (Chr) 3q13.3-21 by fluorescence in situ hybridization (FISH). By somatic cell hybrid analysis, the gene was localized to human Chr 3 (hybridization to other chromosomes was not observed) and rat Chr 11. By interspecific backcross analysis, the Casr gene segregated with D16Mit4 on mouse Chr 16. These findings extend our knowledge of the synteny conservation of human Chr 3, rat Chr 11, and mouse Chr 16.
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