ArticlePflugers Archiv : European journal of physiology1996
Coexpression of the beta2 subunit does not induce voltage-dependent facilitation of the class C L-type Ca channel.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- The impact of the CACNB2 Rs11013860 polymorphism on grey matter volume and brain function in bipolar disorder.BMC psychiatry · 2025Article
- Article
- The Cav1.2 N terminus contains a CaM kinase site that modulates channel trafficking and function.Pflugers Archiv : European journal of physiology · 2015Article
- Functional role of voltage gated Ca(2+) channels in heart automaticity.Frontiers in physiology · 2015Review
- Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels.Frontiers in physiology · 2014Review
- The ß subunit of voltage-gated Ca2+ channels.Physiological reviews · 2010Review
- New Determinant for the CaVbeta2 subunit modulation of the CaV1.2 calcium channel.The Journal of biological chemistry · 2008Article
- Block of CaV1.2 channels by Gd3+ reveals preopening transitions in the selectivity filter.The Journal of general physiology · 2007Article
- The L-type calcium channel in the heart: the beat goes on.The Journal of clinical investigation · 2005Review
- Modulation of the voltage sensor of L-type Ca2+ channels by intracellular Ca2+.The Journal of general physiology · 2004Article
- Slow deactivation and U-shaped inactivation properties in cloned Cav1.2b channels in Chinese hamster ovary cells.Biophysical journal · 2003Article
- Potentiation of the cardiac L-type Ca(2+) channel (alpha(1C)) by dihydropyridine agonist and strong depolarization occur via distinct mechanisms.The Journal of general physiology · 2001Article
- Ca(2+) channel inactivation heterogeneity reveals physiological unbinding of auxiliary beta subunits.Biophysical journal · 2001Article
- Functional roles of gamma2, gamma3 and gamma4, three new Ca2+ channel subunits, in P/Q-type Ca2+ channel expressed in Xenopus oocytes.The Journal of physiology · 2001Article
- The [beta]2a subunit is a molecular groom for the Ca2+ channel inactivation gate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels.Biophysical journal · 2000Article
- Structures and functions of calcium channel beta subunits.Journal of bioenergetics and biomembranes · 1998Review
- Post-translational modifications of beta subunits of voltage-dependent calcium channels.Journal of bioenergetics and biomembranes · 1998Review
- G-Protein-dependent facilitation of neuronal alpha1A, alpha1B, and alpha1E Ca channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-dependent facilitation of L-type Ca2+ channels is an important regulatory mechanism by which excitable cells modulate Ca2+ entry during a train of action potentials. Expression of the alpha1 and beta subunits of the alpha1C Ca2+ channel is necessary and sufficient to reproduce this kind of facilitation in Xenopus oocytes. Here we show that, by expressing the alpha1C together with different beta subunits in oocytes, the beta1, beta3 and beta4, but not the beta2 subunits are permissive for Ca2+ channel facilitation. The poor facilitation observed in rat ventricular cells, together with the presence of the beta2 subunit mRNA, suggest that beta2 may be the beta subunit associated with functional cardiac L-type Ca2+ channels.
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8596729W2013532971What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.