ArticlePflugers Archiv : European journal of physiology1996
A molecular scheme for the reaction between gamma-aminobutyric acid and the most abundant chloride channel on crayfish deep extensor abdominal muscle.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 12 citations in OpenAlex.
- Application of a spike sorting procedure to analyze recordings in the crayfish ventral superficial flexor preparation: A high resolution approach to the study of neuromodulators on axons and synapses.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2014Article
- Characterization and molecular reaction scheme of a chloride channel expressed after axotomy in crayfish.Pflugers Archiv : European journal of physiology · 1996Article
- Neuromuscular glutamatergic and GABAergic channels.Invertebrate neuroscience : INReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-channel measurements were performed with the aim of constructing a detailed molecular scheme for the reaction between gamma-aminobutyric acid (GABA) and a chloride channel of crayfish deep extensor abdominal muscle (DEAM). GABA was applied in pulses to outside-out patches of muscle membrane, and, based on the dose-response of the peak currents and of their rise times, a linear model with five binding steps has been proposed. Evaluation of the single-channel kinetics indicated at least three open states. Two of them originate most probably from the fully liganded receptor state and are grouped in mixed bursts due to their different life times. The third one appears independently, outside the bursts, and originates from a lower liganded receptor state. Simulations of the dose-responses and the open time distributions with this model led to a set of rate constants which generated relatively optimal fits.
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