ArticlePflugers Archiv : European journal of physiology1996
The Ba2+ block of the ATP-sensitive K+ current of mouse pancreatic beta-cells.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Astrocyte gap junctions and KFrontiers in cellular neuroscience · 2025Article
- The Pharmacology of ATP-Sensitive KHandbook of experimental pharmacology · 2021Article
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- Vascular inward rectifier K+ channels as external K+ sensors in the control of cerebral blood flow.Microcirculation (New York, N.Y. : 1994) · 2015Review
- Article
- Rosiglitazone selectively inhibits K(ATP) channels by acting on the K(IR) 6 subunit.British journal of pharmacology · 2012Article
- Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.The Journal of physiology · 2007Article
- Cardiac IK1 underlies early action potential shortening during hypoxia in the mouse heart.Journal of molecular and cellular cardiology · 2007Article
- Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances.The Journal of physiology · 2007Article
- Chloride channel blockers activate an endogenous cationic current in oocytes of Bufo arenarum.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2004Article
- Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes.The Journal of physiology · 1997Article
- GABAB receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying K+ channel Kir6.1 expressed in human embryonic kidney cells.The Journal of physiology · 1996Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We studied the block of whole-cell ATP-sensitive K+ (KATP) currents in mouse pancreatic beta-cells produced by external Ba2+. Ba2+ produced a time-and voltage-dependent block of KATP currents, both the rate and extent of the block increasing with hyperpolarization. With 5.6 mM [K+]o, the relationship between the steady-state KATP current and [Ba2+]o was fit by the Hill equation with a Kd of 12.5 +/- 2.8 microM at -123 mV and of 0.18 +/- 0.02 mM at -62 mV. The Hill coefficient (n) was close to 1 at all potentials indicating that binding of a single Ba2+ ion is sufficient to block the channel. When [K+]o was raised to 28 mM the Kd was little changed (12.4 +/- 4.1 microM at -123 mV, 0.27 +/- 0.05 mM at -62 mV) and n was unaffected, suggesting that K+ does not interact with the Ba2+ binding site. The kinetics of Ba2+ block were slow, 10 microM Ba2+ blocking the KATP current with a time constant of 20 ms at -123 mV in 28 mM [K+]o. The blocking rate constant was calculated as 1.7 mM-1ms-1 and the unblocking rate as 0.02 ms-1, at -123 mV. The data are discussed in terms of a model in which Ba2+ binds to a site at the external mouth of the channel to inhibit the KATP channel.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.