ArticlePflugers Archiv : European journal of physiology1996
Heat shock proteins HSP25, HSP60, HSP72, HSP73 in isoosmotic cortex and hyperosmotic medulla of rat kidney.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 81 citations in OpenAlex.
- Role of heat shock proteins in renal function and adaptation to heat stress: Implications for global warming.World journal of nephrology · 2025Review
- The renal antioxidative effect of losartan involves heat shock protein 70 in proximal tubule cells.Cell stress & chaperones · 2020Review
- Heat shock proteins and kidney disease: perspectives of HSP therapy.Cell stress & chaperones · 2017Review
- Heat shock proteins in the kidney.Pediatric nephrology (Berlin, Germany) · 2016Review
- Chronic ingestion of high dosed Phikud Navakot extraction induces mesangiolysis in rats with alteration of AQP1 and Hsp60 expressions.BioMed research international · 2015Article
- Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70.Journal of translational medicine · 2013Article
- Basal and stress-induced Hsp70 are modulated by ataxin-3.Cell stress & chaperones · 2012Article
- Intracellular mechanisms of aminoglycoside-induced cytotoxicity.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity.Cell death & disease · 2010Article
- Osmoadaptation of Mammalian cells - an orchestrated network of protective genes.Current genomics · 2007Article
- Expression and regulation of alphaB-crystallin in the kidney in vivo and in vitro.Pflugers Archiv : European journal of physiology · 2006Article
- Differential expression of heat shock protein 27 and 70 in renal papillary collecting duct and interstitial cells - implications for urea resistance.The Journal of physiology · 2005Article
- Regulation of expression of the stress response gene, Osp94: identification of the tonicity response element and intracellular signalling pathways.The Biochemical journal · 2004Article
- Upregulation and intrarenal redistribution of heat shock proteins 90alpha and 90beta by low-sodium diet in the rat.Cell stress & chaperones · 2004Article
- TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity.Molecular and cellular biology · 2002Article
- In vivo regulation of MAP kinases in Ratus norvegicus renal papilla by water loading and restriction.The Journal of clinical investigation · 1998Article
- Small heat shock proteins expression in rat kidneys treated with cyclosporine A alone and combined with melatonin.The Histochemical journalArticle
- Serum HSP27 is associated with medullary perfusion in kidney allografts.Journal of nephrologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of heat shock proteins (HSP) HSP60, HSP73, HSP72 and HSP25 in the isoosmotic cortex and the hyperosmotic medulla of the rat kidney was investigated using Western blot analysis and immunohistochemistry. HSP73 was homogeneously distributed throughout the whole kidney. The level of HSP60 was high in the renal cortex and low in the medulla. HSP25 and HSP72 were present in large amounts in the medulla. Only low levels of HSP25 and almost undetectable amounts of HSP72 were found in the cortex. HSP25 exists in one nonphosphorylated and several phosphorylated isoforms. Western blot analysis preceded by isoelectric focussing showed that HSP25 predominates in its nonphosphorylated form in the outer medulla but in its phosphorylated form in cortex and inner medulla. Although this intrarenal distribution pattern was not changed during prolonged anaesthesia (thiobutabarbital sodium), a shift from the nonphosphorylated to the phosphorylated isoforms of HSP25 occurred in the medulla. The characteristic intrarenal distribution of the constitutively expressed HSPs (HSP73, HSP60, HSP25) may reflect different states of metabolic activity in the isoosmotic (cortex) and hyperosmotic (medulla) zones of the kidney. The high content of inducible HSP72 in the medulla most likely is a consequence of the osmotic stress imposed upon the cells by the high urea and salt concentrations in the hyperosmotic medullary environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.