ArticlePflugers Archiv : European journal of physiology1996
Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 144 citations in OpenAlex.
- Ion channels and actin: A tale of two friends.Histology and histopathology · 2025Review
- Exploring the Pathophysiology of ATP-Dependent Potassium Channels in Insulin Resistance.International journal of molecular sciences · 2024Review
- Subcellular trafficking and endocytic recycling of KAmerican journal of physiology. Cell physiology · 2022Review
- Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC.The Journal of biological chemistry · 2020Article
- Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticityFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Targeting a moonlighting function of aldolase induces apoptosis in cancer cells.Cell death & disease · 2019Article
- Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Ionic mechanisms in pancreatic β cell signaling.Cellular and molecular life sciences : CMLS · 2014Review
- Phosphoinositide regulation of TRP channels.Handbook of experimental pharmacology · 2014Review
- ATP-sensitive potassium (KATP) channel activation decreases intraocular pressure in the anterior chamber of the eye.Investigative ophthalmology & visual science · 2011Article
- Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function.Pflugers Archiv : European journal of physiology · 2011Review
- Differential roles for SUR subunits in KATP channel membrane targeting and regulation.American journal of physiology. Heart and circulatory physiology · 2011Article
- Cell membrane stretch activates intermediate-conductance Ca2+-activated K+ channels in arterial smooth muscle cells.Heart and vessels · 2011Article
- Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Ankyrin-B regulates Kir6.2 membrane expression and function in heart.The Journal of biological chemistry · 2010Article
- Channelopathies linked to plasma membrane phosphoinositides.Pflugers Archiv : European journal of physiology · 2010Review
- Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Simultaneous optical mapping of intracellular free calcium and action potentials from Langendorff perfused hearts.Current protocols in cytometry · 2009Article
- PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the cytoskeleton in the rundown and reactivation of adenosine triphosphate (ATP) sensitive K+ channels (KATP channels) was examined by perturbing selectively the intracellular surface of inside-out membrane patches excised from guinea-pig ventricular myocytes. Actin filament-depolymerizing agents (cytochalasins and desoxyribonuclease I) accelerated channel rundown, while actin filament stabilizer (phalloidin) or phosphatidylinositol biphosphate (PIP2; inhibitor of F-actin-severing proteins) inhibited spontaneous and/or Ca2+-induced rundown. When rundown was induced by cytochalasin D or by long exposure to high Ca2+, channel activity could not be restored by exposure to MgATP, but application of F-actin with MgATP could reinstitute channel activity. The processes of rundown and reactivation of cardiac KATP channels may thus be influenced by the assembly and disassembly of the actin cytoskeletal network, which provides a novel regulatory mechanism of this channel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.