ReviewJournal of bioenergetics and biomembranes1995
URF13, a ligand-gated, pore-forming receptor for T-toxin in the inner membrane of cms-T mitochondria.
Review in Journal of bioenergetics and biomembranes, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 91 citations in OpenAlex.
- Mitochondrial-Nuclear Interactions, Co-Transcription, and Adaptive Evolution in Cytoplasmic Male Sterility.Plant, cell & environment · 2026Review
- 3-Hydroxypropanoic acid contributing to pollen abortion in ogura cytoplasmic male sterility of Brassica napus.BMC plant biology · 2026Article
- Winning by Losing: Exploiting Modified Plant Susceptibility Genes to Counteract Necrotrophic Fungal Pathogens.Plant biotechnology journal · 2025Review
- Genetic Resources of Cereal and Oilseed Crops for Heterotic Hybrid Breeding.Plants (Basel, Switzerland) · 2025Review
- Review
- Comparative analysis of mitochondrial genomes of maize CMS-S subtypes provides new insights into male sterility stability.BMC plant biology · 2022Article
- High-generation near-isogenic lines combined with multi-omics to study the mechanism of polima cytoplasmic male sterility.BMC plant biology · 2021Article
- Genome-wide analysis of mRNA and lncRNA expression and mitochondrial genome sequencing provide insights into the mechanisms underlying a novel cytoplasmic male sterility system, BVRC-CMS96, in Brassicarapa.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Organelle genome composition and candidate gene identification for Nsa cytoplasmic male sterility in Brassica napus.BMC genomics · 2019Article
- Cytoplasmic male sterility-associated chimeric open reading frames identified by mitochondrial genome sequencing of four Cajanus genotypes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2013Article
- Alterations of mitochondrial protein assembly and jasmonic acid biosynthesis pathway in Honglian (HL)-type cytoplasmic male sterility rice.The Journal of biological chemistry · 2012Article
- A complete mitochondrial genome sequence of Ogura-type male-sterile cytoplasm and its comparative analysis with that of normal cytoplasm in radish (Raphanus sativus L.).BMC genomics · 2012Article
- Comparative analysis of mitochondrial genomes between a wheat K-type cytoplasmic male sterility (CMS) line and its maintainer line.BMC genomics · 2011Article
- The Ogura sterility-inducing protein forms a large complex without interfering with the oxidative phosphorylation components in rapeseed mitochondria.Plant molecular biology · 2009Article
- Interactions of mitochondrial and nuclear genes that affect male gametophyte development.The Plant cell · 2004Review
- Differential expression of alternative oxidase genes in maize mitochondrial mutants.The Plant cell · 2002Article
- A polyketide synthase is required for fungal virulence and production of the polyketide T-toxin.The Plant cell · 1996Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
URF13 is the product of a mitochondrial-encoded gene (T-urf13) found only in maize plants containing the Texas male-sterile cytoplasm (cms-T), and it is thought to be responsible for both cytoplasmic male sterility and the susceptibility of cms-T maize to the fungal pathogens Bipolaris maydis race T and Phyllosticata maydis. Mitochondria isolated from cms-T maize are uniquely sensitive to pathotoxins (T-toxin) produced by these fungi and to methomyl (a commercial insecticide). URF13 acts as a receptor that specifically binds T-toxin to produce hydrophilic pores in the inner mitochondrial membrane. When expressed in Escherichia coli cells, URF13 also forms hydrophilic pores in the plasma membrane if exposed to T-toxin or methomyl. Topological studies established that URF13 contains three membrane-spanning alpha-helices, two of which are amphipathic and can contribute to pore formation. Chemical cross-linking of URF13 was used to demonstrate the existence of URF13 oligomers in cms-T mitochondria and E. coli cells. The ability of the carboxylate-specific reagent, N,N'-dicyclohexycarbodiimide, to cross-link URF13 was used in conjunction with site-directed mutagenesis to establish that the URF13 tetramer has a central core consisting of a four-alpha-helical bundle which undergoes a conformational change after interaction with T-toxin or methomyl. Overall, the experimental evidence indicates that URF13 functions as a ligand-gated, pore-forming T-toxin receptor in cms-T mitochondria.
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