ArticleThe American journal of physiology1995
The erythrocyte as a regulator of vascular tone.
Article in The American journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01231165 (Comparative Randomized Single-blind Trial of Amiloride in Coronary Heart Disease), which is not on this map. Cited by 201 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Randomized Single-blind Trial of Amiloride in Coronary Heart Disease
Who cites it
201 citing papers in PubMed.
- Cardiorespiratory and oxygenation responses in iron-deficient anemic women during whole-body exercise under moderate hypoxia.European journal of applied physiology · 2026Trial
- Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP.The Journal of clinical investigation · 2023Trial
- Rho-kinase inhibition improves haemodynamic responses and circulating ATP during hypoxia and moderate intensity handgrip exercise in healthy older adults.The Journal of physiology · 2022Trial
- Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease.Blood transfusion = Trasfusione del sangue · 2020Trial
- Plasma Nucleotide Dynamics during Exercise and Recovery in Highly Trained Athletes and Recreationally Active Individuals.BioMed research international · 2018Trial
- Temperature-dependent release of ATP from human erythrocytes: mechanism for the control of local tissue perfusion.Experimental physiology · 2012Trial
- Adenosine receptor antagonist and augmented vasodilation during hypoxic exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Trial
- Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: role of erythrocyte count and oxygenation state of haemoglobin.The Journal of physiology · 2006Trial
- Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle.The Journal of physiology · 2004Trial
- Metabolic modulation of sympathetic vasoconstriction in human skeletal muscle: role of tissue hypoxia.The Journal of physiology · 2000Trial
- When Red Blood Cells Meet Carbon Monoxide: Yin and Yang in Medicines and Pharmaceuticals.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Influence of leukocyte adhesion on partitioning of healthy and diabetic red blood cells at vascular bifurcations.Biophysical journal · 2026Article
- Muscle oxygenation regulation in physical therapy and rehabilitation.Medical gas research · 2026Review
- Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery.Purinergic signalling · 2025Article
- The heart, a secondary organ in the control of blood circulation.Experimental physiology · 2025Review
- Development of thin-film micro-outlets for spatially constraining local POFrontiers in physiology · 2025Article
- Interaction of macro- and microvascular function underlies brachial artery flow-mediated dilation in humans.American journal of physiology. Heart and circulatory physiology · 2024Article
- Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hypoxia induces robust ATP release from erythrocytes in ApoE-LDLR double-deficient mice.Frontiers in physiology · 2024Article
- Alteration in the number, morphology, function, and metabolism of erythrocytes in high-altitude polycythemia.Frontiers in physiology · 2024Article
141 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Local regulation of microvascular blood flow is a complex process in which the needs of the tissue must be communicated to the vasculature, enabling the appropriate matching of O2 supply to demand. We hypothesize that the red blood cell is not only the major O2 carrier but also serves as an O2 sensor and affecter of changes in O2 delivery via its release of ATP, which subsequently binds to P2y receptors on the vascular endothelium, altering vessel caliber. Using the hamster as a model, we determined that the efflux of ATP from red blood cells after exposure to low-PO2 (PO2 = 17 +/- 6 mmHg) and low-pH (pH = 7.06 +/- 0.07) solutions was significantly (P < 0.01) greater than that after exposure to normoxic, normal pH (PO2 = 87 +/- 4; pH = 7.38 +/- 0.04) solutions, indicating that two factors that are associated with an impaired O2 supply relative to demand increase the release of ATP from the red blood cell. To ascertain whether ATP alters vascular caliber, we applied 10(-6) M ATP intraluminally to arterioles of the retractor muscle, using a micropressure system. Vessel diameter increased 8 and 10%, 140 +/- 60 microns upstream of the site of infusion after 50- and 500-ms pulses, respectively. Application of ATP to arteriolar and venular capillaries induced a 31 and 81% increase in red blood cell supply rate, respectively. These results support our hypothesis that the red blood cell is more than just an O2 carrier and has a direct role in the regulation of vascular tone.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.