ArticleEnvironmental health perspectives1995
Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens.
Article in Environmental health perspectives, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 232 citations in OpenAlex.
- In utero exposure to diethylstilbestrol and blood DNA methylation in adult women: Results from a meta-analysis of two cohort studies.Environmental research · 2023Pooled it
- Review
- Microbes as Resources to Remove PPCPs and Improve Water Quality.Microbial biotechnology · 2025Review
- Oral exposure to bisphenol S is associated with alterations in the oviduct proteome of an ovine model, with aggravated effects in overfed females.BMC genomics · 2024Article
- Imprinting and Reproductive Health: A Toxicological Perspective.International journal of molecular sciences · 2023Review
- Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement.Biomedicines · 2023Review
- Obesity III: Obesogen assays: Limitations, strengths, and new directions.Biochemical pharmacology · 2022Review
- Evidence for germline non-genetic inheritance of human phenotypes and diseases.Clinical epigenetics · 2020Review
- Review
- Systematic Review and Meta-analysis of Testicular Germ Cell Tumors Following In Utero Exposure to Diethylstilbestrol.JNCI cancer spectrum · 2019Article
- Reproductive and hormone-related outcomes in women whose mothers were exposed in utero to diethylstilbestrol (DES): A report from the US National Cancer Institute DES Third Generation Study.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Timing of Exposure and Bisphenol-A: Implications for Diabetes Development.Frontiers in endocrinology · 2018Review
- A 4-year study of the proportional distribution of male reproductive organ abnormalities in cattle slaughtered at Nyagatare abattoir, Eastern Rwanda.Veterinary medicine and science · 2017Article
- Impact of oocytes with CLCG on ICSI outcomes and their potential relation to pesticide exposure.Journal of ovarian research · 2017Article
- Epidemiology of Uterine Fibroids: From Menarche to Menopause.Clinical obstetrics and gynecology · 2016Review
- Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs).Reviews in endocrine & metabolic disorders · 2015Review
- Article
- Prenatal diethylstilbestrol exposure and risk of uterine leiomyomata in the Nurses' Health Study II.American journal of epidemiology · 2014Article
- Exposure to diethylstilbestrol during sensitive life stages: a legacy of heritable health effects.Birth defects research. Part C, Embryo today : reviews · 2013Review
- Endocrine disruptors and falling sperm counts: lessons learned or not!Asian journal of andrology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concerns have been raised regarding the role of environmental and dietary estrogens as possible contributors to an increased incidence of various abnormalities in estrogen-target tissues of both sexes. These abnormalities include breast cancer, endometriosis, fibroids, and uterine adenocarcinoma in females, as well as alterations in sex differentiation, decreased sperm concentrations, benign prostatic hyperplasia, prostatic cancer, testicular cancer, and reproductive problems in males. Whether these concerns are valid remains to be determined; however, studies with the potent synthetic estrogen diethylstilbestrol (DES) suggest that exogenous estrogen exposure during critical stages of development can result in permanent cellular and molecular alterations in the exposed organism. These alterations manifest themselves in the female and male as structural, functional, or long-term pathological changes including neoplasia. Although DES has potent estrogenic activity, it may be used as a model compound to study the effects of weaker environmental estrogens, many of which may fit into the category of endocrine disruptors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.