ArticleMolecular biology of the cell1995
A role for Hsp90 in retinoid receptor signal transduction.
Article in Molecular biology of the cell, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 82 citations in OpenAlex.
- The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease.International journal of molecular sciences · 2018Review
- Role of PARP-1 in prostate cancer.American journal of clinical and experimental urology · 2015Review
- HSP90 inhibitor AUY922 induces cell death by disruption of the Bcr-Abl, Jak2 and HSP90 signaling network complex in leukemia cells.Genes & cancer · 2015Article
- High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance.Cancer research · 2010Article
- Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions.Molecular endocrinology (Baltimore, Md.) · 2008Review
- cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis.Molecular and cellular biology · 2007Article
- Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response.PLoS biology · 2004Article
- Altered localization of retinoid X receptor alpha coincides with loss of retinoid responsiveness in human breast cancer MDA-MB-231 cells.Molecular and cellular biology · 2004Article
- Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1.Molecular and cellular biology · 2003Article
- Heat shock protein 90 and the nuclear transport of progesterone receptor.Cell stress & chaperones · 2001Article
- Role of chaperones in nuclear translocation and transactivation of steroid receptors.Endocrine · 2001Review
- The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies.Genes & development · 2000Article
- The Hsp90 chaperone complex A potential target for cancer therapy?World journal of gastroenterology · 1999Article
- Genetic analysis of viable Hsp90 alleles reveals a critical role in Drosophila spermatogenesis.Genetics · 1999Article
- Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome.The EMBO journal · 1998Article
- Hsp90 is required for pheromone signaling in yeast.Molecular biology of the cell · 1998Article
- Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins.Molecular and cellular biology · 1998Article
- Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ubiquitous heat shock protein Hsp90 appears to participate directly in the function of a broad range of cellular signal transduction components, including steroid hormone receptors; however, an evolutionarily related subclass of intracellular receptors, exemplified by the retinoid receptors RAR and RXR, had been inferred from biochemical studies to function independently of Hsp90. To examine this issue genetically, we measured mammalian and avian retinoid receptor activity in a Saccharomyces cerevisiae strain in which the expression of the yeast Hsp90 homologue could be conditionally repressed approximately 20-fold relative to wild type. We tested transcriptional activation by RAR or RXR-RAR, from two types of retinoic acid response elements, triggered by three different agonist ligands. In every condition, we found that activation was severely compromised under conditions of low Hsp90 expression. We showed that the defect was in signal transduction rather than transcription activation per se, and that high affinity hormone binding was abolished in extracts of cells producing low levels of Hsp90. We suggest that Hsp90 may function in at least one step of signal transduction by all members of the intracellular receptor superfamily.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.