ArticleMolecular biology of the cell1995
BET3 encodes a novel hydrophilic protein that acts in conjunction with yeast SNAREs.
Article in Molecular biology of the cell, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
- TRAPPopathies: Severe Multisystem Disorders Caused by Variants in Genes of the Transport Protein Particle (TRAPP) Complexes.International journal of molecular sciences · 2024Review
- The TRAPP complexes: oligomeric exchange factors that activate the small GTPases Rab1 and Rab11.FEBS letters · 2023Review
- The substrate specificity of the human TRAPPII complex's Rab-guanine nucleotide exchange factor activity.Communications biology · 2020Article
- The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.The Journal of biological chemistry · 2019Article
- The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases.The Journal of cell biology · 2018Article
- Article
- Review
- The SMS domain of Trs23p is responsible for the in vitro appearance of the TRAPP I complex in Saccharomyces cerevisiae.Cellular logistics · 2012Article
- Mutational analysis of the yeast TRAPP subunit Trs20p identifies roles in endocytic recycling and sporulation.PloS one · 2012Article
- Entry and exit mechanisms at the cis-face of the Golgi complex.Cold Spring Harbor perspectives in biology · 2011Review
- New links between vesicle coats and Rab-mediated vesicle targeting.Seminars in cell & developmental biology · 2011Review
- Role of Rab GTPases in membrane traffic and cell physiology.Physiological reviews · 2011Review
- Establishing a role for the GTPase Ypt1p at the late Golgi.Traffic (Copenhagen, Denmark) · 2010Article
- Role of vesicle tethering factors in the ER-Golgi membrane traffic.FEBS letters · 2009Review
- The TRAPP complex: insights into its architecture and function.Traffic (Copenhagen, Denmark) · 2008Review
- Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- mBet3p is required for homotypic COPII vesicle tethering in mammalian cells.The Journal of cell biology · 2006Article
- RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics.PLoS pathogens · 2006Article
- Mutants in trs120 disrupt traffic from the early endosome to the late Golgi.The Journal of cell biology · 2005Article
- Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.The EMBO journal · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Here we report the identification of BET3, a new member of a group of interacting genes whose products have been implicated in the targeting and fusion of endoplasmic reticulum (ER) to Golgi transport vesicles with their acceptor compartment. A temperature-sensitive mutant in bet3-1 was isolated in a synthetic lethal screen designed to identify new genes whose products may interact with BET1, a type II integral membrane protein that is required for ER to Golgi transport. At 37 degrees C, bet3-1 fails to transport invertase, alpha-factor, and carboxypeptidase Y from the ER to the Golgi complex. As a consequence, this mutant accumulates dilated ER and small vesicles. The SNARE complex, a docking/fusion complex, fails to form in this mutant. Furthermore, BET3 encodes an essential 22-kDa hydrophilic protein that is conserved in evolution, which is not a component of this complex. These findings support the hypothesis that Bet3p may act before the assembly of the SNARE complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.