ArticleMolecular biology of the cell1995
The Neurospora organelle motor: a distant relative of conventional kinesin with unconventional properties.
Article in Molecular biology of the cell, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 101 citations in OpenAlex.
- Kinesin-1 autoinhibition facilitates the initiation of dynein cargo transport.The Journal of cell biology · 2023Article
- Kinesin Motors in the Filamentous Basidiomycetes in Light of theJournal of fungi (Basel, Switzerland) · 2022Review
- Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle.Cell death and differentiation · 2020Article
- Cell Biology of Hyphal Growth.Microbiology spectrum · 2017Review
- Redistribution of soil water by a saprotrophic fungus enhances carbon mineralization.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Endocytosis and early endosome motility in filamentous fungi.Current opinion in microbiology · 2014Review
- The Arabidopsis kinesin gene AtKin-1 plays a role in the nuclear division process during megagametogenesis.Plant cell reports · 2014Article
- Hyphal growth: a tale of motors, lipids, and the Spitzenkörper.Eukaryotic cell · 2007Review
- Flexibility of the neck domain enhances Kinesin-1 motility under load.Biophysical journal · 2006Article
- Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent.The Journal of cell biology · 2006Article
- Conventional kinesin mediates microtubule-microtubule interactions in vivo.Molecular biology of the cell · 2006Article
- Review: regulation mechanisms of Kinesin-1.Journal of muscle research and cell motility · 2006Review
- Myosin-V, Kinesin-1, and Kinesin-3 cooperate in hyphal growth of the fungus Ustilago maydis.Molecular biology of the cell · 2005Article
- The E-hook of tubulin interacts with kinesin's head to increase processivity and speed.Biophysical journal · 2005Article
- The complex interplay between the neck and hinge domains in kinesin-1 dimerization and motor activity.Molecular biology of the cell · 2005Article
- Role of Unc104/KIF1-related motor proteins in mitochondrial transport in Neurospora crassa.Molecular biology of the cell · 2005Article
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.Microbiology and molecular biology reviews : MMBR · 2004Review
- A class-V myosin required for mating, hyphal growth, and pathogenicity in the dimorphic plant pathogen Ustilago maydis.The Plant cell · 2003Article
- Single fungal kinesin motor molecules move processively along microtubules.Biophysical journal · 2003Article
- Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum.Journal of muscle research and cell motility · 2002Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "conventional" kinesins comprise a conserved family of molecular motors for organelle transport that have been identified in various animal species. Organelle motors from other phyla have not yet been analyzed at the molecular level. Here we report the identification, biochemical and immunological characterization, and molecular cloning of a cytoplasmic motor in a "lower" eukaryote, the Ascomycete fungus Neurospora crassa. This motor, termed Nkin (for Neurospora kinesin), exhibits several unique structural and functional features, including a high rate of microtubule transport, a lack of copurifying light chains, a second P-loop motif, and an overall sequence organization reminiscent of a kinesin-like protein. However, a greater than average sequence homology in the motor domain and the presence of a highly conserved region in the C-terminus identify Nkin as a distant relative of the family of conventional kinesins. A molecular phylogenetic analysis suggests Nkin to have diverged early in the evolution of this family of motors. The discovery of Nkin may help identify domains important for specific biological functions in conventional kinesins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.