ArticleMolecular biology of the cell1995
Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells.
Article in Molecular biology of the cell, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
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- Screening of ferrocenyl-phosphines identifies a gold-coordinated derivative as a novel anticancer agent for hematological malignancies.RSC advances · 2018Article
- Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival.Molecular and cellular biology · 2015Article
- Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independently of catalytic function.Journal of cell science · 2014Article
- CD44-positive cells are candidates for astrocyte precursor cells in developing mouse cerebellum.Cerebellum (London, England) · 2012Article
- Article
- Improved serum-free culture conditions for the differentiation of human and murine fibrocytes.Journal of immunological methods · 2009Article
- SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling.Molecular and cellular biology · 2004Article
- Susceptibility to apoptosis in different murine muscle cell lines.Journal of muscle research and cell motility · 2003Article
- v-Src generates a p53-independent apoptotic signal.Molecular and cellular biology · 2000Article
- Regulation of tumor growth and metastasis of human melanoma by the CREB transcription factor family.Molecular and cellular biochemistry · 2000Article
- The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal.Molecular biology of the cell · 2000Article
- Mitochondria and apoptosis: HQ or high-security prison?Journal of clinical immunology · 1999Review
- The activity of differentiation factors induces apoptosis in polyomavirus large T-expressing myoblasts.Molecular biology of the cell · 1998Article
- Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen.Journal of virology · 1998Article
- A role for caspases in lens fiber differentiation.The Journal of cell biology · 1998Article
- Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis.Molecular and cellular biology · 1997Article
- Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal.Journal of bioenergetics and biomembranes · 1997Article
- Kinase cascades regulating entry into apoptosis.Microbiology and molecular biology reviews : MMBR · 1997Review
- Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently proposed that most mammalian cells constitutively express all of the proteins required to undergo programmed cell death (PCD) and undergo PCD unless continuously signaled by other cells not to. Although some cells have been shown to work this way, the vast majority of cell types remain to be tested. Here we tested purified fibroblasts isolated from developing or adult rat sciatic nerve, a mixture of cell types isolated from normal or p53-null mouse embryos, an immortalized rat fibroblast cell line, and a number of cancer cell lines. We found the following: 1) All of these cells undergo PCD when cultured at low cell density in the absence of serum and exogenous signaling molecules but can be rescued by serum or specific growth factors, suggesting that they need extracellular signals to avoid PCD. (2) The mixed cell types dissociated from normal mouse embryos can only support one another's survival in culture if they are in aggregates, suggesting that cell survival in embryos may depend on short-range signals. (3) Some cancer cells secrete factors that support their own survival. (4) The survival requirements of a human leukemia cell line change when the cells differentiate. (5) All of the cells studied can undergo PCD in the presence of cycloheximide, suggesting that they constitutively express all of the protein components required to execute the death program.
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