Evidence map›Paper›PMID 8587133›Full record

ArticleJournal of molecular evolution1995

Sequence and evolution of the Drosophila pseudoobscura glycerol-3-phosphate dehydrogenase locus.

R S Wells

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

R S WellsMuseum of Comparative Zoology Laboratories, Harvard University, Cambridge, MA 02138, USA.
Harvard University · US

Funding

GENETIC VARIATION OF PROTEINS IN NATURAL POPULATIONSR01GM021179 · NIGMS · HARVARD UNIVERSITY · PI LEWONTIN, RICHARD C. · 1985 to 1995
–
NIGMS NIH HHS GM21179
6 · The paper itself

Abstract

The Gpdh genomic region has been cloned and sequenced in Drosophila pseudoobscura. A total of 6.8 kb of sequence was obtained, encompassing all eight exons of the gene. The exons have been aligned with the sequence from D. melanogaster, and the rates of synonymous and nonsynonymous substitution have been compared to those of other genes sequenced in these two species. Gpdh has the lowest rate of nonsynonymous substitution yet seen in genes sequenced in both D. pseudoobscura and D. melanogaster. No insertion/deletion events were observed, and the overall architecture of the gene (i.e., intron sites, etc.) is conserved. An interesting amino acid reversal was noted between the D. melanogaster Fast allele and the D. pseudoobscura gene.

Indexed as

Amino Acid SequenceAnimalsBase SequenceCloning, MolecularDrosophilaEvolution, MolecularGlycerolphosphate DehydrogenaseMolecular Sequence DataSequence AlignmentSequence AnalysisGlycerolphosphate Dehydrogenase

Identifiers

PMID8587133
OpenAlexW1969303812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.