ArticleJournal of molecular evolution1995
The Giardia lamblia actin gene and the phylogeny of eukaryotes.
Article in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 94 citations in OpenAlex.
- Structure and Functions of Actin and Actin-Binding Proteins inPathogens (Basel, Switzerland) · 2025Review
- Microscopic and molecular detection ofFrontiers in microbiology · 2024Article
- Molecular typing of the actin gene ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.Nature communications · 2022Article
- Disc and Actin Associated Protein 1 influences attachment in the intestinal parasite Giardia lamblia.PLoS pathogens · 2022Article
- Identification of Actin Filament-Associated Proteins in Giardia lamblia.Microbiology spectrum · 2021Article
- Emerging Functions of Actins and Actin Binding Proteins in Trypanosomatids.Frontiers in cell and developmental biology · 2020Review
- Prevalence and genetic diversity of Trichomonas vaginalis clinical isolates in a targeted population in Xinxiang City, Henan Province, China.Parasites & vectors · 2018Article
- Molecular typing of Trichomonas vaginalis isolates by actin gene sequence analysis and carriage of T. vaginalis viruses.Parasites & vectors · 2017Article
- Tetrahymena thermophila: a divergent perspective on membrane traffic.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014Review
- An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Identification of a putative mitochondrial RNA polymerase from Physarum polycephalum: characterization, expression, purification, and transcription in vitro.Current genetics · 2006Article
- Giardia lamblia behavior under cytochalasins treatment.Parasitology research · 2006Article
- A new scenario of plastid evolution: plastid primary endosymbiosis before the divergence of the "Plantae," emended.Journal of plant research · 2005Review
- Biology of Giardia lamblia.Clinical microbiology reviews · 2001Review
- Stage-specific expression and targeting of cyst wall protein-green fluorescent protein chimeras in Giardia.Molecular biology of the cell · 2000Article
- The tigA gene is a transcriptional fusion of glycolytic genes encoding triose-phosphate isomerase and glyceraldehyde-3-phosphate dehydrogenase in oomycota.Journal of bacteriology · 1997Article
- Phosphotyrosine signaling and the single cell:metazoan boundary.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Origin and evolution of the slime molds (Mycetozoa)Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Intron "sliding" and the diversity of intron positions.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The single-copy actin gene of Giardia lamblia lacks introns; it has an average of 58% amino acid identity with the actin of other species; and 49 of its amino acids can be aligned with the amino acids of a consensus sequence of heat shock protein 70. Analysis of the potential RNA secondary structure in the transcribed region of the G. lamblia actin gene and of the single-copy actin gene of nine other species did not reveal any conserved structures. The G. lamblia actin sequence was used to root the phylogenetic trees based on 65 actin protein sequences from 43 species. This tree is congruent with small-subunit rRNA trees in that it shows that oomycetes are not related to higher fungi; that kineto-platid protozoans, green plants, fungi and animals are monophyletic groups; and that the animal and fungal lineages share a more recent common ancestor than either does with the plant lineage. In contrast to small-subunit rRNA trees, this tree shows that slime molds diverged after the plant lineage. The slower rate of evolution of actin genes of slime molds relative to those of plants, fungi, and animals species might be responsible for this incongruent branching.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.