ArticleJournal of molecular evolution1995
Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins.
Article in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C.Nucleic acids research · 2002Article
- Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains.Molecular and cellular biology · 1997Article
- Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated the human homologue of Mok2 gene encoding a Krüppel-like protein. The identification of three cDNAs and genomic clones reveals that the human protein shows substantial structural differences with the mouse MOK2 protein. The mouse MOK2 protein is composed of seven tandem zinc-finger motifs with five additional amino acids at the COOH-terminal. This structural feature is also present at the end of the human MOK2 protein. The seven zinc-finger motifs show 94% identity between the two proteins. In addition, the human protein contains three additional zinc-finger motifs in tandem with the others and a nonfinger acidic domain of 173 amino acids at the NH2-terminal. The Southern analysis indicates that a single copy of these two genes is present in the genome. The human gene has been localized on chromosome 19 on band q13.2-q13.3. The comparison of human and mouse cDNA sequences reveals a strong identity in the sequences localized outside the seven highly conserved zinc-finger motifs. The divergence from their common ancestor results in the loss of a potential transcription activator domain in mouse MOK2 protein.
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