ReviewJournal of molecular evolution1995
Substitution rates in hepatitis delta virus.
Review in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Constraint of Base Pairing on HDV Genome Evolution.Viruses · 2021Article
- Human hepatitis D virus-specific T cell epitopes.JHEP reports : innovation in hepatology · 2021Review
- Diversification of mammalian deltaviruses by host shifting.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Identification of novel avian and mammalian deltaviruses provides new insights into deltavirus evolution.Virus evolution · 2021Article
- Development and performance of prototype serologic and molecular tests for hepatitis delta infection.Scientific reports · 2018Article
- Positive selection of hepatitis delta antigen in chronic hepatitis D patients.Journal of virology · 2007Article
- Molecular evolution of the hepatitis delta virus antigen gene: recombination or positive selection?Journal of molecular evolution · 2004Article
- Genetic polymorphism and natural selection in the malaria parasite Plasmodium falciparum.Genetics · 1998Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Substitution rates were estimated for the coding and noncoding regions of the hepatitis delta virus (HDV). The estimated rates of synonymous substitution in HDV were lower than the rates of substitution at non-synonymous sites and in the noncoding region. HDV has lower synonymous substitution rates than the hepatitis C virus, though both are RNA viruses. The relatively low rate of synonymous substitution in HDV may be due to a strong preference of G and C nucleotides at third codon positions. Variation in substitution rate among HDV lineages may be correlated with the clinical development of the HDV-induced hepatitis. The phylogenetic tree inferred for 24 HDV strains reveals similarities between lineages isolated from the same geographic region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.