ArticleJournal of molecular evolution1995
Interhomologue sequence variation of alpha satellite DNA from human chromosome 17: evidence for concerted evolution along haplotypic lineages.
Article in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Envisioning a new era: Complete genetic information from routine, telomere-to-telomere genomes.American journal of human genetics · 2023Review
- Complete genomic and epigenetic maps of human centromeres.Science (New York, N.Y.) · 2022Article
- The time is ripe to investigate human centromeres by long-read sequencing†.DNA research : an international journal for rapid publication of reports on genes and genomes · 2021Article
- Review
- Rapid and ongoing evolution of repetitive sequence structures in human centromeres.Science advances · 2020Article
- Genomic and functional variation of human centromeres.Experimental cell research · 2020Review
- CENP-A binding domains and recombination patterns in horse spermatocytes.Scientific reports · 2019Article
- Review
- Centromere Repeats: Hidden Gems of the Genome.Genes · 2019Review
- Alpha satellite DNA biology: finding function in the recesses of the genome.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Review
- Linear assembly of a human centromere on the Y chromosome.Nature biotechnology · 2018Article
- α satellite DNA variation and function of the human centromere.Nucleus (Austin, Tex.) · 2017Article
- Ribosomal RNA Genes Contribute to the Formation of Pseudogenes and Junk DNA in the Human Genome.Genome biology and evolution · 2017Article
- Diversity and distribution of alpha satellite DNA in the genome of an Old World monkey: Cercopithecus solatus.BMC genomics · 2016Article
- Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles.Genome research · 2016Article
- Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus.BMC genomics · 2014Article
- Centromere reference models for human chromosomes X and Y satellite arrays.Genome research · 2014Article
- Article
- Functional epialleles at an endogenous human centromere.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Alpha satellite DNA is a family of tandemly repeated DNA found at the centromeres of all primate chromosomes. Different human chromosomes 17 in the population are characterized by distinct alpha satellite haplotypes, distinguished by the presence of variant repeat forms that have precise monomeric deletions. Pair-wise comparisons of sequence diversity between variant repeat units from each haplotype show that they are closely related in sequence. Direct sequencing of PCR-amplified alpha satellite reveals heterogeneous positions between the repeat units on a chromosome as two bands at the same position on a sequencing ladder. No variation was detected in the sequence and location of these heterogeneous positions between chromosomes 17 from the same haplotype, but distinct patterns of variation were detected between chromosomes from different haplotypes. Subsequent sequence analysis of individual repeats from each haplotype confirmed the presence of extensive haplotype-specific sequence variation. Phylogenetic inference yielded a tree that suggests these chromosome 17 repeat units evolve principally along haplotypic lineages. These studies allow insight into the relative rates and/or timing of genetic turnover processes that lead to the homogenization of tandem DNA families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.