ArticlePflugers Archiv : European journal of physiology1996
Regulation of Ca channel by intracellular Ca2+ and Mg2+ in frog ventricular cells.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Regulation of Cardiac Cav1.2 Channels by Calmodulin.International journal of molecular sciences · 2023Review
- Magnesium ions improve vasomotor function in exhausted rats.PloS one · 2023Article
- Cooperative regulation of Ca(v)1.2 channels by intracellular Mg(2+), the proximal C-terminal EF-hand, and the distal C-terminal domain.The Journal of general physiology · 2009Article
- Voltage-dependent modulation of L-type calcium currents by intracellular magnesium in rat ventricular myocytes.Archives of biochemistry and biophysics · 2007Article
- Channel phosphorylation and modulation of L-type Ca2+ currents by cytosolic Mg2+ concentration.American journal of physiology. Cell physiology · 2006Article
- Regulation of L-type calcium current by intracellular magnesium in rat cardiac myocytes.The Journal of physiology · 2004Article
- Regulation of L-type Ca2+ channels in the heart: overview of recent advances.Molecular and cellular biochemistry · 2003Review
- Contribution of the plasmalemma to Ca2+ homeostasis in hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Modulation of Ca2+ channels by intracellular Mg2+ ions and GTP in frog ventricular myocytes.Pflugers Archiv : European journal of physiology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of changing the intracellular concentrations of Ca2+ or Mg2+ ([Ca2+]i, [Mg2+]i) on Ca current (ICa) was studied in frog ventricular myocytes using the whole-cell and cell-attached patch clamp techniques. In the physiological range of [Mg2+]i an increase in [Ca2+]i enhanced ICa whereas at lower [Mg2+]i ICa was suppressed. The increase in ICa caused by Ca2+ loading was not mediated by phosphorylation since the kinase inhibitors H-8 ¿N-[2-(methylamino)-ethyl]-5-isoquinolinesulphonamide dihydrochloride¿, staurosporine and KN-62 ¿1-[N,O-bis(5-isoquinolinesulphonyl)-N-methyl-1-tyrosyl]-4- phenylpiperizine¿ and a non-hydrolysable adenosine 5'-triphosphate analogue beta,gamma-methyleneadenosine 5'-triphosphate did not prevent the Ca2+-induced ICa increase. ICa was dramatically increased from 10+/-6 (n=4) to 71+/-7 nA/nF (n=4) when [Mg2+]i was lowered from 1.0 x 10(-3) to 1.0 x 10(-6) M at a [Ca2+]i of 10(-8) M. The concentration response relation for inhibition of Ca channels by [Mg2+]i is modulated by [Ca2+]i. To account for the experimental results it is postulated that competitive binding of Ca2+ or Mg2+ to the Ca channel accelerates the transition of the channel from an active to a silent mode. Single-channel recordings support this hypothesis. The regulation may have clinical relevance in cytoprotection during cardiac ischaemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.