Evidence map›Paper›PMID 8584415›Full record

ArticlePflugers Archiv : European journal of physiology1995

Effect of temperature on spontaneous Ca2+-activated Cl- currents in rabbit portal vein cells.

R M Helliwell, W A Large

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Effects of temperature on pacemaker potentials in the mouse small intestine.Pflugers Archiv : European journal of physiology · 2007
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

R M HelliwellDepartment of Pharmacology and Clinical Pharmacology, St. George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
W A Large
St George's Hospital · GBSt George's, University of London · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The effect of temperature on the time course of spontaneous transient inward (Ca2+-activated Cl-) currents (STICs) was investigated with the perforated patch technique in rabbit portal vein cells. STICs decayed exponentially at temperatures between 17 degrees C and 35 degrees C. The time constant of the decay (tau ) was decreased with increasing temperature and had a temperature coefficient, Q10, of 2.6. The temperature sensitivity of tau could be described by the Arrhenius equation which gave an activation energy of 16kcal/mol. This result indicates that STIC decay is governed by a single first-order reaction and provides further support for the hypothesis that the decay is due to the gating properties of Ca2+-activated Cl- channels.

Indexed as

AnimalsCalciumCell MembraneChloride ChannelsElectrophysiologyIn Vitro TechniquesMembrane PotentialsMuscle, Smooth, VascularPatch-Clamp TechniquesPortal VeinRabbitsTemperatureCalciumChloride Channels

Identifiers

PMID8584415
OpenAlexW2327232289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.