ArticlePflugers Archiv : European journal of physiology1995
Changes of pH affect calcium currents but not outward potassium currents in rat myometrial cells.
Article in Pflugers Archiv : European journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Lactate in Amniotic Fluid: Predictor of Labor Outcome in Oxytocin-Augmented Primiparas' Deliveries.PloS one · 2016Article
- Physiological increases in lactate inhibit intracellular calcium transients, acidify myocytes and decrease force in term pregnant rat myometrium.The Journal of physiology · 2015Article
- Mechanisms of action of pH-induced effects on vascular smooth muscle.Molecular and cellular biochemistry · 2004Article
- Intracellular calcium homeostasis changes induced in rat spinal cord neurons by extracellular acidification.Neurochemical research · 2003Article
- In vivo pH and metabolite changes during a single contraction in rat uterine smooth muscle.The Journal of physiology · 1999Article
- Properties of voltage-activated [Ca2+]i transients in single smooth muscle cells isolated from pregnant rat uterus.The Journal of physiology · 1998Article
- Hypoxia and smooth muscle function: key regulatory events during metabolic stress.The Journal of physiology · 1998Review
- Stimulus-dependent modulation of smooth muscle intracellular calcium and force by altered intracellular pH.Pflugers Archiv : European journal of physiology · 1996Article
- Changes in intracellular pH close to term and their possible significance to labour.Pflugers Archiv : European journal of physiology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Spontaneous contraction of uterine smooth muscle is enhanced by alkalinization and depressed by acidification. We have investigated the ionic currents responsible for this in single myometrial cells. Intracellular acidification (20 mM butyrate) at constant external pH depressed the magnitude of the calcium current to 58+/-6% of control, but had little effect on outward currents. Similar but slower effects were also observed when the extracellular pH was lowered to 6.9 (56+/-9% of control). Correspondingly, when the intracellular or extracellular pH was elevated (20 mM NH4Cl or pH 7.9 respectively) the calcium current magnitude increased (165+/-15% in NH4Cl; 136+/-2% at pH 7.9) and there was, again, no effect on the outward currents. These observations are consistent with the effects of pH on spontaneous contractile activity being due to an effect on the membrane calcium current.
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