ArticleGenetics1995
Loss of spatial control of the mitotic spindle apparatus in a Chlamydomonas reinhardtii mutant strain lacking basal bodies.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- Epsilon tubulin is an essential determinant of microtubule-based structures in male germ cells.EMBO reports · 2024Article
- Control of division in Chlamydomonas by cyclin B/CDKB1 and the anaphase-promoting complex.PLoS genetics · 2022Article
- Molecular and cellular dynamics of early embryonic cell divisions in Volvox carteri.The Plant cell · 2022Article
- Review
- Regulation of Multiple Fission and Cell-Cycle-Dependent Gene Expression by CDKA1 and the Rb-E2F Pathway in Chlamydomonas.Current biology : CB · 2020Article
- Cell-Type Transcriptomes of the Multicellular Green AlgaG3 (Bethesda, Md.) · 2018Article
- Volvox: A simple algal model for embryogenesis, morphogenesis and cellular differentiation.Developmental biology · 2016Review
- The basal bodies of Chlamydomonas reinhardtii.Cilia · 2016Review
- The Chlamydomonas cell cycle.The Plant journal : for cell and molecular biology · 2015Review
- Green algae and the origins of multicellularity in the plant kingdom.Cold Spring Harbor perspectives in biology · 2014Review
- Review
- Independent localization of plasma membrane and chloroplast components during eyespot assembly.Eukaryotic cell · 2013Article
- Statistical method for comparing the level of intracellular organization between cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Exotic mitotic mechanisms.Open biology · 2012Review
- Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells.The Journal of cell biology · 2012Article
- IFT proteins accumulate during cell division and localize to the cleavage furrow in Chlamydomonas.PloS one · 2012Article
- Asymmetric properties of the Chlamydomonas reinhardtii cytoskeleton direct rhodopsin photoreceptor localization.The Journal of cell biology · 2011Article
- Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei.Journal of cell science · 2010Article
- Influence of centriole number on mitotic spindle length and symmetry.Cytoskeleton (Hoboken, N.J.) · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
The bld2-1 mutation in the green alga Chlamydomonas reinhardtii is the only known mutation that results in the loss of centrioles/basal bodies and the loss of coordination between spindle position and cleavage furrow position during cell division. Based on several different assays, bld2-1 cells lack basal bodies in > 99% of cells. The stereotypical cytoskeletal morphology and precise positioning of the cleavage furrow observed in wild-type cells is disrupted in bld2-1 cells. The positions of the mitotic spindle and of the cleavage furrow are not correlated with respect to each other or with a specific cellular landmark during cell division in bld2-1 cells. Actin has a variable distribution during mitosis in bld2-1 cells, but this aberrant distribution is not correlated with the spindle positioning defect. In both wild-type and bld2-1 cells, the position of the cleavage furrow is coincident with a specialized set of microtubules found in green algae known as the rootlet microtubules. We propose that the rootlet microtubules perform the functions of astral microtubules and that functional centrioles are necessary for the organization of the cytoskeletal superstructure critical for correct spindle and cleavage furrow placement in Chlamydomonas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.