Evidence map›Paper›PMID 8582634›Full record

ArticleGenetics1995

Roles of ABF1, NPL3, and YCL54 in silencing in Saccharomyces cerevisiae.

S Loo, P Laurenson, M Foss, A Dillin, J Rine

Abstract readComparative Study
In one paragraph

Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

S LooDepartment of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
P Laurenson
M Foss
A Dillin
J Rine
University of California, Berkeley · US

Funding

GENETIC ANALYSIS OF THE GENES CONTROLLING A POSITIONR01GM031105 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RINE, JASPER D · 1985 to 2020
$6.4M
VIROLOGY AND CHRONIC INFECTIONP30ES001896 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, MARTYN T · 1985 to 2003
$4.7M
GENETIC ANALYSIS OF GENES CONTROLLING A POSITION EFFECTR37GM031105 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RINE, JASPER D · 1999 to 2008
$3.5M
NIEHS NIH HHS P30ESO1896-12NIGMS NIH HHS GM-31105
6 · The paper itself

Abstract

A sensitized genetic screen was carried out to identify essential genes involved in silencing in Saccharomyces cerevisiae. This screen identified temperature-sensitive alleles of ORC2 and ORC5, as described elsewhere, and ABF1, NPL3, and YCL54, as described here. Alleles of ABF1 that caused silencing defects provided the genetic proof of Abflp's role in silencing. The roles of Npl3p and Ycl54p are less clear. These proteins did not act exclusively through any one of the three protein binding sites of the HMR-E silencer. Unlike the orc2, orc5, and abf1 mutations that were isolated in the same (or a similar) screen for silencing mutants, neither temperature-sensitive mutation in NPL3 or YCL54 caused overt replication defects.

Indexed as

Gene Expression Regulation, FungalMethyltransferasesRNA-Binding ProteinsSaccharomyces cerevisiae ProteinsTranscription, GeneticAllelesAmino Acid SequenceCell CycleDNA-Binding ProteinsEscherichia coliFungal ProteinsMating FactorMolecular Sequence DataMutagenesisNuclear ProteinsPeptidesABF1 protein, S cerevisiaeDNA-Binding ProteinsFungal ProteinsMating FactorMethyltransferasesNPL3 protein, S cerevisiaeNuclear ProteinsPeptidesRNA-Binding ProteinsSaccharomyces cerevisiae ProteinsSPB1 protein, S cerevisiaeTranscription Factors

Identifiers

PMID8582634
PMCPMC1206852
OpenAlexW2170185555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.