ArticleGenetics1995
A random model approach to interval mapping of quantitative trait loci.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- FiMAP: A fast identity-by-descent mapping test for biobank-scale cohorts.PLoS genetics · 2023Article
- Article
- Estimating genetic variance contributed by a quantitative trait locus: A random model approach.PLoS computational biology · 2022Article
- Statistical power in genome-wide association studies and quantitative trait locus mapping.Heredity · 2019Article
- Genetic Architecture of Soybean Yield and Agronomic Traits.G3 (Bethesda, Md.) · 2018Article
- How do the type of QTL effect and the form of the residual term influence QTL detection in multi-parent populations? A case study in the maize EU-NAM population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Practical considerations regarding the use of genotype and pedigree data to model relatedness in the context of genome-wide association studies.G3 (Bethesda, Md.) · 2013Article
- A triad of highly divergent polymeric immunoglobulin receptor (PIGR) haplotypes with major effect on IgA concentration in bovine milk.PloS one · 2013Article
- Genetic mapping of complex traits by minimizing integrated square errors.BMC genetics · 2012Article
- Joint analysis of quantitative trait loci and major-effect causative mutations affecting meat quality and carcass composition traits in pigs.BMC genetics · 2011Article
- Systems mapping: how to improve the genetic mapping of complex traits through design principles of biological systems.BMC systems biology · 2011Article
- Article
- Genome-wide evaluation for quantitative trait loci under the variance component model.Genetica · 2010Article
- Epistasis: obstacle or advantage for mapping complex traits?PloS one · 2010Article
- A statistical model for mapping morphological shape.Theoretical biology & medical modelling · 2010Article
- A gene frequency model for QTL mapping using Bayesian inference.Genetics, selection, evolution : GSE · 2010Article
- Bayesian shrinkage mapping of quantitative trait loci in variance component models.BMC genetics · 2010Article
- A new Bayesian automatic model selection approach for mapping quantitative trait loci under variance component model.Genetica · 2009Article
- Mapping QTLs with digenic epistasis under multiple environments and predicting heterosis based on QTL effects.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2007Article
- A computational approach for functional mapping of quantitative trait loci that regulate thermal performance curves.PloS one · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Mapping quantitative trait loci in outbred populations is important because many populations of organisms are noninbred. Unfortunately, information about the genetic architecture of the trait may not be available in outbred populations. Thus, the allelic effects of genes can not be estimated with ease. In addition, under linkage equilibrium, marker genotypes provide no information about the genotype of a QTL (our terminology for a single quantitative trait locus is QTL while multiple loci are referred to as QTLs). To circumvent this problem, an interval mapping procedure based on a random model approach is described. Under a random model, instead of estimating the effects, segregating variances of QTLs are estimated by a maximum likelihood method. Estimation of the variance component of a QTL depends on the proportion of genes identical-by-descent (IBD) shared by relatives at the locus, which is predicted by the IBD of two markers flanking the QTL. The marker IBD shared by two relatives are inferred from the observed marker genotypes. The procedure offers an advantage over the regression interval mapping in terms of high power and small estimation errors and provides flexibility for large sibships, irregular pedigree relationships and incorporation of common environmental and fixed effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.