ArticleGenetics1995
Evolutionary consequences of mutation and selection within an individual.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Stepwise emergence of recombination suppression precedes fissiparous asexuality in the planarian Schmidtea mediterranea.Nature communications · 2026Article
- Somatic Evolution of Stem Cell Mutations in Long-Lived Plants.Molecular biology and evolution · 2025Article
- Genetic diversity within a tree and alternative indexes for different evolutionary effects.Quantitative plant biology · 2024Article
- Developmental Selection and the Perception of Mutation Bias.Molecular biology and evolution · 2023Article
- Mutations in coral soma and sperm imply lifelong stem cell renewal and cell lineage selection.Proceedings. Biological sciences · 2023Article
- Are mutations usually deleterious? A perspective on the fitness effects of mutation accumulation.Evolutionary ecology · 2022Article
- Nuclear-specific gene expression in heterokaryons of the filamentous ascomyceteProceedings. Biological sciences · 2022Article
- Multicellularity in animals: The potential for within-organism conflict.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Population-level consequences of inheritable somatic mutations and the evolution of mutation rates in plants.Proceedings. Biological sciences · 2021Article
- Estimation of the SNP Mutation Rate in Two Vegetatively Propagating Species of Duckweed.G3 (Bethesda, Md.) · 2020Article
- Somatic genetic drift and multilevel selection in a clonal seagrass.Nature ecology & evolution · 2020Article
- Together stronger: Intracolonial genetic variability occurrence inEcology and evolution · 2020Article
- Somatic mutations substantially increase the per-generation mutation rate in the coniferEvolution letters · 2019Article
- Outstanding intraindividual genetic diversity in fissiparous planarians (Dugesia, Platyhelminthes) with facultative sex.BMC evolutionary biology · 2019Article
- Evolutionary maintenance of genomic diversity within arbuscular mycorrhizal fungi.Ecology and evolution · 2019Article
- Nonclonal coloniality: Genetically chimeric colonies through fusion of sexually produced polyps in the hydrozoanEvolution letters · 2018Article
- Quantifying natural seasonal variation in mutation parameters with mutation accumulation lines.Ecology and evolution · 2018Article
- Increase in viability due to the accumulation of X chromosome mutations in Drosophila melanogaster males.Genetica · 2018Article
- Idiosyncratic Genome Degradation in a Bacterial Endosymbiont of Periodical Cicadas.Current biology : CB · 2017Article
- Adaptive Evolution under Extreme Genetic Drift in Oxidatively Stressed Caenorhabditis elegans.Genome biology and evolution · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Whether in sexual or asexual organisms, selection among cell lineages during development is an effective way of eliminating deleterious mutations. Using a mathematical analysis, we find that relatively small differences in cell replication rates during development can translate into large differences in the proportion of mutant cells within the adult, especially when development involves a large number of cell divisions. Consequently, intraorganismal selection can substantially reduce the deleterious mutation rate observed among offspring as well as the mutation load within a population, because cells rather than individuals provide the selective "deaths" necessary to stem the tide of deleterious mutations. The reduction in mutation rate among offspring is more pronounced in organisms with plastic development than in those with structured development. It is also more pronounced in asexual organisms that produce multicellular rather than unicellular offspring. By effecting the mutation rate, intraorganismal selection may have broad evolutionary implications; as an example, we consider its influence on the evolution of ploidy levels, finding that cell-lineage selection is more effective in haploids and tends to favor their evolution.
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