ArticleDiabetologia1995
Modulation by high glucose of adhesion molecule expression in cultured endothelial cells.
Article in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 100 citations in OpenAlex.
- Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachment.Stem cell reports · 2026Article
- Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice.Science translational medicine · 2025Article
- Investigation of enhanced adhesion of HEK293T cells on SAM-modified ITO surfaces using NMR metabolomics.Frontiers in bioengineering and biotechnology · 2025Article
- ETS proto-oncogene 1 modulates PTP1B expression to participate in high glucose-mediated endothelial inflammation.Acta biochimica et biophysica Sinica · 2022Article
- Anti-Inflammatory Effects of Quercetin on High-Glucose and Pro-Inflammatory Cytokine Challenged Vascular Endothelial Cell Metabolism.Molecular nutrition & food research · 2021Article
- Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease.Oxidative medicine and cellular longevity · 2019Review
- Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality.NPJ aging and mechanisms of disease · 2017 · on this mapArticle
- Propofol protects against high glucose-induced endothelial adhesion molecules expression in human umbilical vein endothelial cells.Cardiovascular diabetology · 2013Article
- Article
- Mitochondrial function in vascular endothelial cell in diabetes.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2012Review
- The paradox of the neutrophil's role in tissue injury.Journal of leukocyte biology · 2011Review
- Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Anti-inflammatory properties of C-Peptide.The review of diabetic studies : RDS · 2009Article
- Expression of CD18 on the neutrophils of patients with diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2007Article
- Cardiovascular disease in diabetic nephropathy patients: cell adhesion molecules as potential markers?Vascular health and risk management · 2005Review
- Plasma matrix metalloproteinases, low density lipoprotein oxidisability and soluble adhesion molecules after a glucose load in Type 2 diabetes.Cardiovascular diabetology · 2004Article
- Short-term mortality of myocardial infarction patients with diabetes or hyperglycaemia during admission.Journal of epidemiology and community health · 2002Article
- Levamisole induced apoptosis in cultured vascular endothelial cells.British journal of pharmacology · 2000Article
- IgG anti-endothelial cell antibodies (AECA) in type I diabetes mellitus; induction of adhesion molecule expression in cultured endothelial cells.Clinical and experimental immunology · 1998Article
- Elevated circulating adhesion molecules in NIDDM--potential mediators in diabetic macroangiopathy.Diabetologia · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the influence of high ambient glucose on cellular expression of adhesion molecules, known to mediate endothelial interaction of leucocytes and monocytes. Paired cultures of individual isolates of human umbilical vein endothelial cells (HUVECs) were studied by fluorescence activated cell sorter analysis after exposure to 30 vs 5 mmol/l glucose. Incubation of HUVECs for 24h in 30 mmol/l glucose increased ICAM-1 (intercellular adhesion molecule-1; 116.4 +/- 16.9% of control, p < or = 0.05), but not PECAM (platelet endothelial cell adhesion molecule) expression, compared to cultures kept in 5 mmol/l glucose. Long-term exposure (13 +/- 1 days) of HUVECs to 30 mmol/l glucose increased expression of ICAM-1 to 122.5 +/- 32.2% (p < 0.002) and reduced that of PECAM to 86.9 +/- 21.3% vs the respective control culture in 5 mmol/l glucose (p < 0.02). Stimulation of confluent HUVECs, kept in 30 vs 5 mmol/l glucose for 13 +/- 1 days, with 20 U/ml interleukin-1 for 24 h (ICAM-1) and 4 h (endothelial leukocyte adhesion molecule 1) resulted in reduced ICAM-1 (84.8 +/- 27.0%, p < 0.05) and endothelial leukocyte adhesion molecule-1 (87.6 +/- 22.4%, p < 0.05) expression vs control cells, while that of PECAM (t:24 h) and vascular cell adhesion molecule-1 (t: 16 h) remained unchanged. In conclusion, it appears that differences in expression of adhesion molecules on HUVECs in response to high glucose reflects endothelial glucose toxicity, which may also induce endothelial dysfunction in diabetes.
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