Trial reportDiabetologia1995
Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.
Trial report in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 214 citations in OpenAlex.
- β-Cell lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight/obese adolescents.The Journal of clinical endocrinology and metabolism · 2013Trial
- Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects.American journal of physiology. Endocrinology and metabolism · 2009Trial
- Role of lipids in development of noninsulin-dependent diabetes mellitus: lessons learned from Pima Indians.Lipids · 1996Trial
- Effects of Hypertriglyceridemia With or Without NEFA Elevation on β-cell Function and Insulin Clearance and Sensitivity.The Journal of clinical endocrinology and metabolism · 2025Article
- Interplay of fatty acids, insulin and exercise in vascular health.Lipids in health and disease · 2025Review
- Metabolic Responses to High-Fat Feeding and Chronic Psychological Stress Combination.Endocrinology, diabetes & metabolism · 2024Article
- Non-Alcoholic Fatty Liver Disease or Type 2 Diabetes Mellitus-The Chicken or the Egg Dilemma.Biomedicines · 2023Review
- Cellular Senescence in Obesity and Associated Complications: a New Therapeutic Target.Current diabetes reports · 2022Review
- The Role of Beta Cell Recovery in Type 2 Diabetes Remission.International journal of molecular sciences · 2022Review
- Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro.Antioxidants (Basel, Switzerland) · 2022Article
- Why does obesity cause diabetes?Cell metabolism · 2022Review
- Linoleic acid and the regulation of glucose homeostasis: A review of the evidence.Prostaglandins, leukotrienes, and essential fatty acids · 2021Review
- Effect of free fatty acids on insulin secretion, insulin sensitivity and incretin effect - a narrative review.Archives of endocrinology and metabolism · 2021Review
- Plasma Fatty Acid Composition Was Associated with Apelin Gene Expression in Human Adipose Tissues.BioMed research international · 2021Article
- Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes.Journal of molecular biology · 2020Review
- Article
- What role do fat cells play in pancreatic tissue?Molecular metabolism · 2019Review
- Effects of acute NEFA manipulation on incretin-induced insulin secretion in participants with and without type 2 diabetes.Diabetologia · 2018Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our study investigates short- and long-term effects of infusion of non-esterified fatty acids (NEFA) on insulin secretion in healthy subjects. Twelve healthy individuals underwent a 24-h Intralipid (10% triglyceride emulsion) infusion at a rate of 0.4 ml/min with a simultaneous infusion of heparin (a bolus of 200 U followed by 0.2 U/min per kg body weight). After an overnight fast (baseline), at 6 and at 24 h of Intralipid infusion and 24 h after Intralipid discontinuation (recovery test), all subjects underwent an intravenous glucose tolerance test (iv-GTT) (25 g of glucose/min). Intralipid infusion caused a threefold rise in plasma NEFA concentrations with no difference between the 6- and the 24-h concentrations. Compared to baseline acute insulin response (AIR) (AIR = 63 +/- 8 mU/l), short-term (6-h) Intralipid infusion was associated with a significant increase in AIR (86 +/- 12 mU/l p < 0.01); in contrast, long-term (24-h) Intralipid delivery was associated with inhibition of AIR (31 +/- 5 mU/l) compared to baseline (p < 0.001) and to the 6-h (p < 0.03) triglyceride emulsion infusion. Intralipid infusion was associated with a progressive and significant decline in respiratory quotient (RQ). A positive correlation between changes in fasting plasma NEFA concentrations and AIR at the 6-h infusion (r = 0.89 p < 0.001) was found. In contrast, at the end of the Intralipid infusion period, changes in plasma NEFA concentrations and AIR were negatively correlated (r = -0.87 p < 0.001). The recovery test showed that fasting plasma NEFA concentrations, RQ and AIR had returned to baseline values. In the control study (n = 8) 0.9% NaCl infusion did not mimick the effect of Intralipid. In conclusion, our study demonstrates that short- and long-term exposures of beta cells to high plasma NEFA concentrations have opposite effects on glucose-induced insulin secretion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.