ArticleDiabetologia1995
Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats.
Article in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 114 citations in OpenAlex.
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- A novel animal model of impaired glucose tolerance induced by the interaction of vitamin E deficiency and (60)Co radiation.BioMed research international · 2015Article
- Vitamin C in disease prevention and cure: an overview.Indian journal of clinical biochemistry : IJCB · 2013Review
- Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury.PloS one · 2011Article
- Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat.Neurotoxicity research · 2010Article
- Vitamin E (alpha-tocopherol) supplementation in diabetic rats: effects on the proximal colon.BMC gastroenterology · 2009Article
- Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum.Journal of molecular histology · 2008Article
- Myenteric neurons and intestinal mucosa of diabetic rats after ascorbic acid supplementation.World journal of gastroenterology · 2008Article
- Neuroprotective effects of high-dose vs low-dose melatonin after blunt sciatic nerve injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2008Article
- Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study.Neurobiology of aging · 2006Article
- Advances in diabetes for the millennium: vitamins and oxidant stress in diabetes and its complications.MedGenMed : Medscape general medicine · 2004Review
- Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat.Molecular and cellular biochemistry · 2004Article
- Article
- Reactive oxygen species, apoptosis and altered NGF-induced signaling in PC12 pheochromocytoma cells cultured in elevated glucose: an in vitro cellular model for diabetic neuropathy.Neurotoxicity research · 2001Article
- Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes.The Journal of clinical investigation · 1997Article
- Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats.Diabetologia · 1996Article
- Reversal of peripheral nerve conduction and perfusion deficits by the free radical scavenger, BM15.0639, in diabetic rats.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta.Diabetologia · 1995Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Increased generation of reactive oxygen species, coupled with impaired endogenous scavenging mechanisms, plays a prominent role in the aetiology of neurovascular abnormalities in experimental diabetes mellitus. We examined the efficacy of the natural anti-oxidants vitamins C, E and beta-carotene in preventing nerve conduction and nutritive blood flow deficits in streptozotocin-diabetic rats. One month of diabetes caused a 19.1% reduction in sciatic motor conduction velocity (p < 0.001). This was approximately prevented 80-90% by high-dose (1000 mg.kg-1.day-1) vitamin E and beta-carotene treatments (p < 0.001). Vitamin C had lesser effects; the maximum protection found for motor conduction velocity was 36% using a dose of 150 mg.kg-1.day-1 (p < 0.001). High dose (500 mg.kg-1.day-1 (p < 0.001). High dose (500 mg.kg-1.day-1) vitamin C had a lesser effect on conduction than intermediate doses. Joint vitamin C and lower dose (500 mg.kg-1.day-1) vitamin E treatment had a predominantly additive preventive effect against nerve dysfunction. Resistance to hypoxic conduction failure for sciatic nerve in vitro was markedly increased by diabetes and this remained relatively unaffected by treatment. Sciatic nutritive endoneurial blood flow, measured using microelectrode polarography and hydrogen clearance, was reduced 46.1% by 1 month of diabetes (p < 0.001). This was prevented to the extent of 87%, 36% and 98% by vitamins E, C and beta-carotene, respectively (p < 0.01). These data emphasize the role of oxidative stress in the development of early neurovascular changes in experimental diabetes and show that naturally available scavengers have a neuroprotective action.
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