ArticleCell and tissue research1995
Physiological dilation of uteroplacental arteries in the guinea pig depends on nitric oxide synthase activity of extravillous trophoblast.
Article in Cell and tissue research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 127 citations in OpenAlex.
- Targeted Intracellular Delivery of Amino Acids to Trophoblast Cells Reveals Proteomic Signatures of Cellular Utilisation.Biomolecules · 2026Article
- A Novel Dual-Function Nitric Oxide Donor Therapy for Preeclampsia-A Proof-of-Principle Study in a Murine Model.Antioxidants (Basel, Switzerland) · 2023Article
- Reliability of Rodent and Rabbit Models in Preeclampsia Research.International journal of molecular sciences · 2022Review
- The Spiny Mouse-A Menstruating Rodent to Build a Bridge From Bench to Bedside.Frontiers in reproductive health · 2021Review
- Bradykinin Exerts Independent Effects on Trophoblast Invasion and Blood Pressure in Pregnant Guinea Pigs.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Review
- Association of pregnancy-associated plasma protein A and vascular endothelial growth factor with pregnancy-induced hypertension.Experimental and therapeutic medicine · 2019Article
- The Role of Uric Acid in Preeclampsia: Is Uric Acid a Causative Factor or a Sign of Preeclampsia?Current hypertension reports · 2018Review
- Resolution of inflammation pathways in preeclampsia-a narrative review.Immunologic research · 2017Review
- Developmental origins of metabolic disorders: The need for biomarker candidates and therapeutic targets from adequate preclinical models.EuPA open proteomics · 2016Article
- A review of inter- and intraspecific variation in the eutherian placenta.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Ly49 receptors activate angiogenic mouse DBA⁺ uterine natural killer cells.Cellular & molecular immunology · 2014Article
- Administration of angiotensin II and a bradykinin B2 receptor blocker in midpregnancy impairs gestational outcome in guinea pigs.Reproductive biology and endocrinology : RB&E · 2014Article
- Utero-placental expression of angiotensin-(1-7) and ACE2 in the pregnant guinea-pig.Reproductive biology and endocrinology : RB&E · 2013Article
- Bradykinin promotes migration and invasion of human immortalized trophoblasts.Reproductive biology and endocrinology : RB&E · 2011Article
- Challenges posed to the maternal circulation by pregnancy.Integrated blood pressure control · 2011Article
- Vasodilator factors in the systemic and local adaptations to pregnancy.Reproductive biology and endocrinology : RB&E · 2009Review
- Oxygen as modulator of trophoblast invasion.Journal of anatomy · 2009Review
- Review
- Maternal uterine vascular remodeling during pregnancy.Physiology (Bethesda, Md.) · 2009Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The trophoblast invasion of uteroplacental arteries in the guinea pig has been studied by means of electron microscopy and immunohistochemisty. To identify trophoblast cells, smooth muscle cells, and endothelial cells, antibodies against cytokeratins, smooth muscle myosin, desmin, and vimentin were employed. Furthermore, the immunohistochemical expression patterns of nitric oxide synthase isoforms (eNOS, mNOS and bNOS) were studied and were compared with the enzyme histochemical staining for NADPH-diaphorase. Dilation of uteroplacental arteries begins prior to day 30, when trophoblast cells that coexpress endothelial and macrophage nitric oxide synthase can be found in the vicinity of the vessels and replace the surrounding peritoneal mesothelium. Trophoblast invasion of the arterial walls and the subsequent wall destruction are only secondary effects. Starting around day 50, the final steps of pregnancy-dependent vessel modifications involve intraarterial trophoblast adhesion to the endothelium and subsequent replacement of the endothelium by the trophoblast cells. These may centrifugally invade the vessel media eventually forming intraluminal plugs. These findings led us to the conclusion that in the guinea pig pregnancy-induced physiological dilation of the uteroplacental arteries is due to the effect of nitric oxide rather than being caused by trophoblast-induced media destruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.