ArticleBiophysical journal1995
Single cytoplasmic dynein molecule movements: characterization and comparison with kinesin.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 186 citations in OpenAlex.
- Measuring molecular forces inside living cells using magnetic tweezers.Biophysical reviews · 2025Review
- Nuclear deformation by microtubule molecular motors.PLoS computational biology · 2025Article
- Nonmuscle myosin 2 filaments are processive in cells.Biophysical journal · 2023Article
- Non-muscle myosin 2 filaments are processive in cells.bioRxiv : the preprint server for biology · 2023Article
- Processivity and Velocity for Motors Stepping on Periodic Tracks.Biophysical journal · 2020Article
- Crowd Control: Effects of Physical Crowding on Cargo Movement in Healthy and Diseased Neurons.Frontiers in cellular neuroscience · 2019Review
- Article
- Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers.Biophysical journal · 2018Article
- Motor Proteins.Cold Spring Harbor perspectives in biology · 2018Review
- Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Geometric Asymmetry Induces Upper Limit of Mitotic Spindle Size.Biophysical journal · 2017Article
- Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia.Nature communications · 2017Article
- Gene Electrotransfer: A Mechanistic Perspective.Current gene therapy · 2016Review
- Cytoskeletal Network Morphology Regulates Intracellular Transport Dynamics.Biophysical journal · 2015Article
- The Kinesin-8 Kip3 switches protofilaments in a sideward random walk asymmetrically biased by force.Biophysical journal · 2015Article
- Mechanism and regulation of cytoplasmic dynein.Annual review of cell and developmental biology · 2015Review
- Impact-Free Measurement of Microtubule Rotations on Kinesin and Cytoplasmic-Dynein Coated Surfaces.PloS one · 2015Article
- Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport.Nature cell biology · 2014Article
- Cooperative protofilament switching emerges from inter-motor interference in multiple-motor transport.Scientific reports · 2014Article
- Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.Science (New York, N.Y.) · 2014Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cytoplasmic dynein is a major microtubule motor for minus-end directed movements including retrograde axonal transport. To better understand the mechanism by which cytoplasmic dynein converts ATP energy into motility, we have analyzed the nanometer-level displacements of latex beads coated with low numbers of cytoplasmic dynein molecules. Cytoplasmic dynein-coated beads exhibited greater lateral movements among microtubule protofilaments (ave. 5.1 times/microns of displacement) compared with kinesin (ave. 0.9 times/micron). In addition, dynein moved rearward up to 100 nm over several hundred milliseconds, often in correlation with off-axis movements from one protofilament to another. We suggest that single molecules of cytoplasmic dynein move the beads because 1) there is a linear dependence of bead motility on dynein/bead ratio, 2) the binding of beads to microtubules studied by laser tweezers is best fit by a first-order Poisson, and 3) the run length histogram of dynein beads follows a first-order decay. At the cellular level, the greater disorder of cytoplasmic dynein movements may facilitate transport by decreasing the duration of collisions between kinesin and cytoplasmic dynein-powered vesicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.