ArticleBiophysical journal1995
Description of modal gating of the cardiac calcium release channel in planar lipid membranes.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Modulation of KFrontiers in pharmacology · 2020Article
- Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ryanodine Receptor Open Times Are Determined in the Closed State.Biophysical journal · 2018Article
- Quenching the spark: Termination of CICR in the submicroscopic space of the dyad.The Journal of general physiology · 2017Review
- Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2).Molecular pharmacology · 2014Article
- Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle.Molecular pharmacology · 2014Article
- Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP.American journal of physiology. Cell physiology · 2012Article
- Article
- Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: cytoplasmic and luminal regulation modeled in a tetrameric channel.The Journal of general physiology · 2008Article
- A two-gate model for the ryanodine receptor with allosteric modulation by caffeine and quercetin.European biophysics journal : EBJ · 2008Article
- Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.Biophysical journal · 2007Article
- Calcium activation of ryanodine receptor channels--reconciling RyR gating models with tetrameric channel structure.The Journal of general physiology · 2005Article
- A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.Biophysical journal · 2004Article
- Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods.The Journal of general physiology · 2004Article
- Kinetic diversity of single-channel burst openings underlying persistent Na(+) current in entorhinal cortex neurons.Biophysical journal · 2003Article
- Kinetic studies of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles.Biophysical journal · 2003Article
- Effects of quercetin on single Ca(2+) release channel behavior of skeletal muscle.Biophysical journal · 2002Article
- Markovian models of low and high activity levels of cardiac ryanodine receptors.Biophysical journal · 2001Article
- Ryanodine receptor adaptation.The Journal of general physiology · 2000Review
- Questions about adaptation in ryanodine receptors.The Journal of general physiology · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single channel activity of the cardiac ryanodine-sensitive calcium-release channel in planar lipid membranes was studied in order to elucidate the calcium-dependent mechanism of its steady-state behavior. The single channel kinetics, observed with Cs+ as the charge carrier at different activating (cis) Ca2+ concentrations in the absence of ATP and Mg2+, were similar to earlier reports and were extended by analysis of channel modal behavior. The channel displayed three episodic levels of open probability defining three gating modes: H (high activity), L (low activity), and I (no activity). The large difference in open probabilities between the two active modes resulted from different bursting patterns and different proportions of two distinct channel open states. I-mode was without openings and can be regarded as the inactivated mode of the channel; L-mode was composed of short and sparse openings; and H-mode openings were longer and grouped into bursts. Modal gating may explain calcium-release channel adaptation (as transient prevalence of H-mode after Ca2+ binding) and the inhibitory effects of drugs (as stabilization of mode I), and it provides a basis for understanding the regulation of calcium release.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.