ArticleThe American journal of pathology1996
Experimental rabbit models of Chlamydia pneumoniae infection.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 87 citations in OpenAlex.
- The role of infected epithelial cells inFrontiers in cellular and infection microbiology · 2023Review
- Differentiation of bacterial and non-bacterial community-acquired pneumonia by thin-section computed tomography.European journal of radiology · 2009Article
- Development of a hamster model of Chlamydophila pneumoniae infection.Veterinary research communications · 2005Article
- Influence of clarithromycin on early atherosclerotic lesions after Chlamydia pneumoniae infection in a rabbit model.Antimicrobial agents and chemotherapy · 2002Article
- Characterization of antiapoptotic activities of Chlamydia pneumoniae in human cells.Infection and immunity · 2001Article
- Analytical sensitivity, reproducibility of results, and clinical performance of five PCR assays for detecting Chlamydia pneumoniae DNA in peripheral blood mononuclear cells.Journal of clinical microbiology · 2000Article
- Chlamydia pneumoniae and atherosclerosis.Current atherosclerosis reports · 2000Review
- Can an antibiotic (macrolide) prevent Chlamydia pneumoniae-induced atherosclerosis in a rabbit model?Clinical and diagnostic laboratory immunology · 1999Article
- De Novo induction of atherosclerosis by Chlamydia pneumoniae in a rabbit model.Infection and immunity · 1999Article
- Chlamydia pneumoniae and atherosclerosis.Heart (British Cardiac Society) · 1999Review
- Is there an infective aetiology to atherosclerosis?Drugs & aging · 1998Review
- Rabbit model for Chlamydia pneumoniae infection.Journal of clinical microbiology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Chlamydia pneumoniae (TWAR), a common cause of acute respiratory disease in humans, has recently been associated with coronary and aortic atherosclerosis. In this study, we evaluated rabbit models of chlamydial infection to investigate the pathogenesis of C. pneumoniae infection. New Zealand White rabbits were inoculated intranasally and intratracheally with C. pneumoniae, strain AR-39, and primary and repeated infection were assessed. After a single inoculation, lung pathology was characterized by a moderate self-resolving interstitial pneumonia with bronchiolitis of 21 days in duration. Chlamydial DNA was detected by polymerase chain reaction (PCR) intermittently in the upper respiratory tract and lung tissue through day 21 postinoculation, spleen tissue at day 14, and peripheral blood mononuclear cells at days 3 and 21. After repeated inoculations, chlamydial DNA was detected by PCR in the upper respiratory tract and lung tissue through day 42. Lung lesions consisted of multifocal interstitial mononuclear cell aggregates that persisted up to day 42. Watanabe heritable hyperlipidemic rabbits were less susceptible to C. pneumoniae infection. After multiple inoculations of Watanabe rabbits, C. pneumoniae was detected by PCR and/or immunocytochemistry until day 21. In conclusion, C. pneumoniae induced a moderate respiratory infection in these rabbit models.
Indexed as
Identifiers
8579129PMC1861677W151454834What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.