ArticleThe American journal of pathology1996
Matrix metalloproteinase 9 (gelatinase B) is expressed in multinucleated giant cells of human giant cell tumor of bone and is associated with vascular invasion.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 86 citations in OpenAlex.
- A Large Cavernous Sinus Giant Cell Tumor Invading Clivus and Sphenoid Sinus Masquerading as Meningioma: A Case Report and Literature Review.Frontiers in surgery · 2022Article
- Exploring the Proteomic Alterations from Untreated and Cryoablation and Irradiation Treated Giant Cell Tumors of Bone Using Liquid-Chromatography Tandem Mass Spectrometry.Molecules (Basel, Switzerland) · 2020Article
- Meningeal Foam Cells and Ependymal Cells in Axolotl Spinal Cord Regeneration.Frontiers in immunology · 2019Article
- Intratibial injection of patient-derived tumor cells from giant cell tumor of bone elicits osteolytic reaction in nude mouse.Oncology letters · 2018Article
- The Promoting Effect of the Extracellular Matrix Peptide TNIIIA2 Derived from Tenascin-C in Colon Cancer Cell Infiltration.International journal of molecular sciences · 2017Article
- Expression of Matrix Metalloproteinase-9 and CD34 in Giant Cell Tumor of Bone.Orthopaedic surgery · 2016Article
- Giant Cell Tumor of Bone - An Overview.The archives of bone and joint surgery · 2016Review
- Article
- Resistance of MMP9 and TIMP1 to endotoxin tolerance.Pathogens and disease · 2015Article
- Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone.Journal of Cancer · 2015Article
- Ossified soft tissue recurrence of giant cell tumor of the bone: four case reports with follow-up radiographs, CT, ultrasound, and MR images.Skeletal radiology · 2014Article
- A locally invasive giant cell tumor of the skull base: case report.Journal of neurological surgery reports · 2014Article
- Hemostasis and alterations of the central nervous system.Seminars in thrombosis and hemostasis · 2013Review
- Differing Serum Cea in Primary and Recurrent Rectal Cancer - A Reflection of Histology?World journal of oncology · 2012Article
- Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone.The Open bone journal · 2009Article
- Central giant cell granuloma of the jaws and giant cell tumor of long bones: an immunohistochemical comparative study.Journal of applied oral science : revista FOB · 2007Article
- The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis.Pathology oncology research : POR · 2001Review
- MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits.Clinical & experimental metastasis · 2000Article
- 'Proteolytic switching': opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression.British journal of cancer · 1999Article
- Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone.Clinical & experimental metastasis · 1997Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human giant cell tumor (GCT) consists of multinucleated giant cells and mononuclear stromal cells, and is characterized by frequent vascular invasion without distant metastases. To study the role of matrix metalloproteinases (MMPs) in the vascular invasion, we examined production of MMP-1 (tissue collagenase), -2 (gelatinase A), -3 (stromelysin-1), -9 (gelatinase B), and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in GCT. MMP-9 was highly and predominantly expressed in giant cells by both immunohistochemistry and in situ hybridization. Expression of other MMPs was also observed in some cases but was inconstant. Sandwich enzyme immunoassays demonstrated that MMP-9 is the predominant MMP secreted by GCT. There was a definite imbalance between the amounts of MMP-9 and those of TIMPs in the culture media of GCT, leading to detectable gelatinolytic activity in an assay using 14C-gelatin. Gelatin zymography demonstrated the main activity at about 90 kd, which was identified as the zymogen of MMP-9 by immunoblotting. Immunohistochemistry for type IV collagen and laminin, major basement membrane components, showed that disappearance of the proteins is closely associated with MMP-9-positive giant cells. These results indicate the production of MMP-9 by multinucleated giant cells and suggest that the metalloproteinase may contribute to proteolysis associated with vascular invasion and local bone resorption in human GCT.
Indexed as
Identifiers
8579123PMC1861675W63496739What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.