ArticleThe American journal of pathology1996
Chromosomal translocation t(X;18) in human synovial sarcomas analyzed by fluorescence in situ hybridization using paraffin-embedded tissue.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 69 citations in OpenAlex.
- Core Epithelial-to-Mesenchymal Transition Gene Signature Predicts Metastasis and Poor Survival in Synovial Sarcoma.Cancer medicine · 2026Article
- Combination of Photodynamic and Bronchoscopic Intervention With Radiation Therapy in Treating Pulmonary Pleomorphic Sarcoma: A Case Report.The clinical respiratory journal · 2025Article
- Value of Optical Genome Mapping (OGM) for Diagnostics of Rare Diseases: A Family Case Report.Balkan journal of medical genetics : BJMG · 2024Article
- Primary pleuropulmonary synovial sarcoma presenting with recurrent spontaneous pneumothorax.BMJ case reports · 2023Article
- Primary monophasic breast synovial sarcoma in a female patient.BMJ case reports · 2021Article
- Primary Intraosseous Synovial Sarcoma in the Mandible.Case reports in oncological medicine · 2021Article
- Vorinostat synergizes with ridaforolimus and abrogates the ridaforolimus-induced activation of AKT in synovial sarcoma cells.BMC research notes · 2014Article
- Primary pleuropulmonary synovial sarcoma: A report of two cases and review of literature.South Asian journal of cancer · 2013Article
- Novel pathways and molecular targets for the treatment of sarcoma.Current oncology reports · 2013Review
- A microRNA activity map of human mesenchymal tumors: connections to oncogenic pathways; an integrative transcriptomic study.BMC genomics · 2012Article
- Orthopaedic case of the month: ankle pain and swelling in a 23-year-old man.Clinical orthopaedics and related research · 2010Article
- Synovial sarcoma of anterior abdominal wall.The Indian journal of surgery · 2010Article
- Primary monophasic synovial sarcoma presenting as a pulmonary mass: a case report.Journal of medical case reports · 2008Article
- [Simultaneous analysis of t(X;18) by FISH- und SYT/SSX-RT-PCR in synovial sarcoma].Der Pathologe · 2005Article
- The detection of t(14;18) in archival lymph nodes: development of a fluorescence in situ hybridization (FISH)-based method and evaluation by comparison with polymerase chain reaction.The Journal of molecular diagnostics : JMD · 2003Article
- Detection of ALK gene rearrangements in formalin-fixed, paraffin-embedded tissue using a fluorescence in situ hybridization (FISH) probe: a search for optimum conditions of tissue archiving and preparation for FISH.Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology · 2003Article
- [Primary cardiac synovial sarcoma--a case report].The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi · 1998Article
- Use of nonbreakpoint DNA probes to detect the t(X;18) in interphase cells from synovial sarcoma: implications for detection of diagnostic tumor translocations.The American journal of pathology · 1998Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synovial sarcoma is characterized cytogenetically by translocation t(X;18)(p11.2;q11.2). In this study, 28 cases that had been diagnosed initially as synovial sarcoma, including 2 fibrosarcomas, and 1 leiomyosarcoma were collected and examined for translocation t(X;18) on paraffin-embedded tissues by fluorescence in situ hybridization (FISH). Of the synovial sarcomas, 25 showed findings consistent with translocation t(X;18) with an additional copy signal for the total probe of X and 18 chromosomes. The other three cases, as well as the two fibrosarcomas and the leiomyosarcoma, did not show this translocation. One (case 26) of three negative cases was diagnosed finally as leiomyosarcoma and another (case 27) as malignant peripheral nerve sheath tumor from histological and immunohistochemical analysis. Thus, in all, 25 (96%) of 26 synovial sarcomas showed findings consistent with translocation t(X;18). In summary, translocation t(X;18) is a chromosomal aberration specific for synovial sarcoma. The fluorescence in situ hybridization technique can be used even on cells from paraffin-embedded tissues, and is a useful diagnostic aid for synovial sarcoma.
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8579122PMC1861692W113548206What OpenQuestion holds
Registered trials
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