ArticleThe American journal of pathology1996
Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 157 citations in OpenAlex.
- Human herpesvirus 8 (KSHV) contamination of peripheral blood and autograft products from multiple myeloma patients.Bone marrow transplantation · 2000Trial
- Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level.Nature communications · 2024Article
- FSCN1 acts as a promising therapeutic target in the blockade of tumor cell motility: a review of its function, mechanism, and clinical significance.Journal of Cancer · 2022Review
- Review
- Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated Chemotaxis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells.Frontiers in cell and developmental biology · 2021Review
- Review
- Roles of Fascin mRNA expression in colorectal cancer: Meta-analysis and bioinformatics analysis.Molecular and clinical oncology · 2020Article
- CD40-CD40L cross-talk drives fascin expression in dendritic cells for efficient antigen presentation to CD4+ T cells.International immunology · 2017Article
- Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy.The Journal of experimental medicine · 2017Article
- Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway.British journal of cancer · 2014Article
- Fascin confers resistance to Listeria infection in dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Fascin1 promotes cell migration of mature dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules.PloS one · 2011Article
- Article
- Fascin1 is dispensable for mouse development but is favorable for neonatal survival.Cell motility and the cytoskeleton · 2009Article
- Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells.PloS one · 2009Article
- Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice.BMC pulmonary medicine · 2008Article
- Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma.British journal of cancer · 2007Article
- Effects of dendritic cells from cord blood CD34+ cells on human hepatocarcinoma cell line BEL-7402 in vitro and in SCID mice.World journal of gastroenterology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
This study was initiated to examine the differential expression of an evolutionary conserved human 55-kd actin-bundling (p55) protein that is induced in B lymphocytes by Epstein-Barr virus infection. Our study demonstrates that p55 is specifically expressed at constitutively high levels in human peripheral blood dendritic cells and lymph node (interdigitating) dendritic cells. Blood dendritic cells constitute a minority (< 2%) of all blood leukocytes but are a distinct population of potent antigen-presenting cells. Immunofluorescence microscopy with a monoclonal antibody specific for p55 showed that 87% of peripheral blood dendritic cells stained brightly in the cytoplasm and in the veiled cytoplasmic extensions. In contrast, monocytes, granulocytes, T cells, and B lymphocytes showed no expression of the p55 protein. Western blot analysis confirmed that only the dendritic cell component of peripheral blood expressed high levels of p55. Staining of human lymph node sections demonstrated selective expression of the p55 antigen by dendritic cells in the T-cell-dependent areas but not in the B cell follicles. p55 is likely to be involved in the organization of a specialized microfilament cytoskeleton in the dendritic cells, and the anti-p55 antibody should be useful for further characterization of this important population of antigen-presenting cells in clinical transplantation, HIV-1 pathogenesis, and autoimmune diseases.
Indexed as
Identifiers
8579121PMC1861678W45745482What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.