ArticleThe American journal of pathology1996
Expression of CD44 isoforms in renal cell tumors. Positive correlation to tumor differentiation.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Cholesterol depletion decreases adhesion of non-small cell lung cancer cells to E-selectin.American journal of physiology. Cell physiology · 2023Article
- Piezo1 promoted hepatocellular carcinoma progression and EMT through activating TGF-β signaling by recruiting Rab5c.Cancer cell international · 2022Article
- Sema3d Restrained Hepatocellular Carcinoma Progression Through Inactivating Pi3k/Akt SignalingFrontiers in oncology · 2022Article
- Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.Wiley interdisciplinary reviews. RNA · 2018Review
- The clinical significance of CCBE1 expression in human colorectal cancer.Cancer management and research · 2018Article
- ISOexpresso: a web-based platform for isoform-level expression analysis in human cancer.BMC genomics · 2016Article
- Cross-linked hyaluronic acid sub-micron particles: in vitro and in vivo biodistribution study in cancer xenograft model.Journal of materials science. Materials in medicine · 2013Article
- Gene and isoform expression signatures associated with tumor stage in kidney renal clear cell carcinoma.BMC systems biology · 2013Article
- Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer.Colloids and surfaces. B, Biointerfaces · 2012Review
- Prognostic value of CD44 expression in penile squamous cell carcinoma: a pilot study.Cellular oncology (Dordrecht, Netherlands) · 2012Article
- Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- CD44 is associated with tumor recurrence and is an independent poor prognostic factor for patients with localized clear cell renal cell carcinoma after nephrectomy.Experimental and therapeutic medicine · 2012Article
- Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis.Clinical & experimental metastasis · 2008Review
- Prognostic role of CD44 cell adhesion molecule expression in primary and metastatic renal cell carcinoma: a clinicopathologic study of 125 cases.Virchows Archiv : an international journal of pathology · 2008Article
- In vitro evaluation of the astatinated chimeric monoclonal antibody U36, a potential candidate for treatment of head and neck squamous cell carcinoma.European journal of nuclear medicine and molecular imaging · 2005Article
- Expression of osteopontin and CD44 molecule in papillary renal cell tumors.Pathology oncology research : POR · 2005Article
- Article
- Focal loss of CD44 variant protein expression is related to recurrence in superficial bladder carcinoma.The American journal of pathology · 1999Article
- Silencing of the CD44 gene by CpG methylation in a human gastric carcinoma cell line.Japanese journal of cancer research : Gann · 1999Article
- De novo expression of CD44 in prostate carcinoma is correlated with systemic dissemination of prostate cancer.Journal of clinical pathology · 1998Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD44 isoforms have been implicated in tumor progression and embryogenesis. Primary renal cell tumors (n = 100) of various histopathological differentiation and grading stages were analyzed for expression of CD44 isoforms in comparison with nonmalignant adult and fetal renal tissues. Evaluations were performed by immunohistochemistry using CD44 isoform-specific monoclonal antibodies and by reverse transcriptase polymerase chain reactions (RT-PCR). In the nonmalignant kidney no CD44 variant isoforms were detected. There was a significant increase in expression of CD44 standard (CD44s) and several variant isoforms (CD44v) in the course of tumor differentiation in clear cell carcinomas (n = 68) from stages G1 to G3 (P < 0.0001 for CD44s and isoforms containing CD44-6v, and P < 0.007 for those containing CD44-9v). Also, in chromophilic cell carcinomas (n = 13), CD44 isoform expression correlated with grading; ie, no CD44 expression was detected in G1 tumors, whereas in approximately 50% of the G2 tumors, CD44s, CD44-6v, and CD44-9v isoforms were present. Oncocytomas (n = 8), which are benign renal cell tumors, did not express CD44 isoforms, whereas invasive chromophobe cell carcinomas (n = 11) were positive for CD44s and CD44v isoforms. Transcript analyses by RT-PCR revealed that the upregulated isoforms in the carcinoma cells contained exons 8 to 10 and 3, 8 to 10 in combination from the variant region. In conclusion, expression of variant CD44 isoforms was strongly correlated with grading and appears to mediate a more aggressive phenotype to renal cell tumors.
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