ArticleProceedings of the National Academy of Sciences of the United States of America1996
The chicken beta 2-microglobulin gene is located on a non-major histocompatibility complex microchromosome: a small, G+C-rich gene with X and Y boxes in the promoter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 51 citations in OpenAlex.
- Chickens as a simple system for scientific discovery: The example of the MHC.Molecular immunology · 2021Article
- A potential nomenclature for the Immuno Polymorphism Database (IPD) of chicken MHC genes: progress and problems.Immunogenetics · 2020Review
- Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens.Trends in immunology · 2018Review
- Quantitative real-time PCR (qPCR) for Eimeria tenella replication--Implications for experimental refinement and animal welfare.Parasitology international · 2015Article
- Sequence of a complete chicken BG haplotype shows dynamic expansion and contraction of two gene lineages with particular expression patterns.PLoS genetics · 2014Article
- Monoclonal antibodies directed against chicken β2-microglobulin developed with a synthesized peptide.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2013Article
- Primordial linkage of β2-microglobulin to the MHC.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Characterization of the functional domain of β2-microglobulin from the Asian seabass, Lates calcarifer.PloS one · 2010Article
- The chicken BF1 (classical MHC class I) gene shows evidence of selection for diversity in expression and in promoter and signal peptide regions.Immunogenetics · 2009Article
- Chicken TAP genes differ from their human orthologues in locus organisation, size, sequence features and polymorphism.Immunogenetics · 2005Article
- Article
- Mapping of the chicken immunoglobulin heavy-chain constant region gene locus reveals an inverted alpha gene upstream of a condensed upsilon gene.Immunology · 2000Article
- Class II transactivator: mastering the art of major histocompatibility complex expression.Molecular and cellular biology · 2000Review
- Chicken microchromosomes are hyperacetylated, early replicating, and gene rich.Genome research · 1998Article
- Gene homologs on human chromosome 15q21-q26 and a chicken microchromosome identify a new conserved segment.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
beta 2-Microglobulin is an essential subunit of major histocompatibility complex (Mhc) class I molecules, which present antigenic peptides to T lymphocytes. We sequenced a number of cDNAs and two genomic clones corresponding to chicken beta 2-microglobulin. The chicken beta 2-microglobulin gene has a similar genomic organization but smaller introns and higher G+C content than mammalian beta 2-microglobulin genes. The promoter region is particularly G+C-rich and contains, in addition to interferon regulatory elements, potential S/W, X, and Y boxes that were originally described for mammalian class II but not class I alpha or beta 2-microglobulin genes. There is a single chicken beta 2-microglobulin gene that has little polymorphism in the coding region. Restriction fragment length polymorphisms from Mhc homozygous lines, Mhc congenic lines, and backcross families, as well as in situ hybridization, show that the beta 2-microglobulin gene is located on a microchromosome different from the one that contains the chicken Mhc. We propose that the structural similarities between the beta 2-microglobulin and Mhc genes in the chicken are due to their presence on microchromosomes and suggest that these features and the microchromosomes appeared by deletion of DNA in the lineage leading to the birds.
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