ArticleProceedings of the National Academy of Sciences of the United States of America1996
Origin and evolution of circular waves and spirals in Dictyostelium discoideum territories.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 122 citations in OpenAlex.
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- Necessary Condition of Self-Organisation in Nonextensive Open Systems.Entropy (Basel, Switzerland) · 2023Article
- Unraveling the physiochemical nature of colloidal motion waves among silver colloids.Science advances · 2022Article
- Pulsed low-energy stimulation initiates electric turbulence in cardiac tissue.PLoS computational biology · 2021Article
- From environmental sensing to developmental control: cognitive evolution in dictyostelid social amoebas.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
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- Dynamics of diffusive cell signaling relays.eLife · 2020Article
- Challenges Associated with Interpreting Mechanisms of AF.Arrhythmia & electrophysiology review · 2020Review
- Spontaneous center formation in Dictyostelium discoideum.Scientific reports · 2019Article
- Evolution of multicellularity in Dictyostelia.The International journal of developmental biology · 2019Review
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- Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning.Developmental cell · 2017Article
- Fold-change detection and scale invariance of cell-cell signaling in social amoeba.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level: lessons fromInterface focus · 2016Review
- Modeling oscillations and spiral waves in Dictyostelium populations.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Randomly distributed Dictyostelium discoideum cells form cooperative territories by signaling to each other with cAMP. Cells initiate the process by sending out pulsatile signals, which propagate as waves. With time, circular and spiral patterns form. We show that by adding spatial and temporal noise to the levels of an important regulator of external cAMP levels, the cAMP phosphodiesterase inhibitor, we can explain the natural progression of the system from randomly firing cells to circular waves whose symmetries break to form double- and single- or multi-armed spirals. When phosphodiesterase inhibitor is increased with time, mimicking experimental data, the wavelength of the spirals shortens, and a proportion of them evolve into pairs of connected spirals. We compare these results to recent experiments, finding that the temporal and spatial correspondence between experiment and model is very close.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.